Acute necrotizing encephalopathy: Combined therapy and favorable outcome in a new case

Renzo Manara, Malida Franzoi, Paola Cogo, Pier Antonio Battistella

Research output: Contribution to journalArticle

Abstract

Background: Acute necrotizing encephalopathy (ANE) is a rare disease characterized by multiple, symmetrical brain lesions, affecting thalami, brainstem tegmentum, and cerebellar medulla; more inconstantly, other structures are involved, i.e., internal capsules, posterolateral putamen, and deep periventricular white matter. Features: The clinical picture consists of rapidly deteriorating acute monophasic encephalopathy preceded by prodromal febrile illness; the symptoms include hyperpyrexia, convulsions, recurrent vomiting, and coma within 24 h. Prognosis: The outcome is usually poor and approximately 70% of the patients die within a few days from the onset of fever. There is no specific therapy for ANE but, in some patients, the clinical status improved with steroid treatment.

Original languageEnglish
Pages (from-to)1231-1236
Number of pages6
JournalChild's Nervous System
Volume22
Issue number10
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Acute encephalopathy
  • Acute necrotizing encephalopathy
  • ANE
  • Infant sand children
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

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