Acute neurotoxicity after yohimbine ingestion by a body builder

Andrea Giampreti, Davide Lonati, Carlo Locatelli, Loretta Rocchi, Maria Teresa Campailla

Research output: Contribution to journalArticlepeer-review


Yohimbine is an alkaloid obtained from the Corynanthe yohimbe tree and other biological sources. Yohimbine is currently approved in the United States for erectile dysfunction and has undergone resurgence in street use as an aphrodisiac and mild hallucinogen. In recent years yohimbine use has become common in body-building communities for its presumed lipolytic and sympathomimetic effects. We describe a 37-year-old bodybuilder in which severe acute neurotoxic effects occurred in 2 h after yohimbine ingestion. The patient presented with malaise, vomiting, loss of consciousness, and repeated seizures after ingestion of 5 g of yohimbine during a body-building competition in a gymnasium. His Glasgow Coma Score was 3, requiring orotracheal intubation. Two hours after admission, vital signs were blood pressure 259107 mmHg and heart rate 140 beatsmin. Treatment with furosemide, labetalol, clonidine, and urapidil and gastrointestinal decontamination were performed. Twelve hours later the patient was extubated with normal hemodynamic parameters and neurological examination. The yohimbine blood levels at 3, 6, 14, and 22 h after ingestion were 5,240; 2,250; 1,530; and 865 ngmL, respectively, with a mean half-life of 2 h. Few data are available about yohimbine toxicity and the related blood levels. This is a case of a large ingestion of yohimbine in which severe hemodynamic and neurological manifestations occurred and elevated blood levels of yohimbine were detected.

Original languageEnglish
Pages (from-to)827-829
Number of pages3
JournalClinical Toxicology
Issue number8
Publication statusPublished - 2009


  • Acute poisoning
  • Dietary supplement
  • Overdose
  • Plasmatic dosage
  • Toxicokinetics

ASJC Scopus subject areas

  • Toxicology


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