Acute nonlymphocytic leukemia: Evidence of clonogenic cells in peripheral blood in early complete remission

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We describe a patient with acute nonlymphocytic leukemia in whom chromosomal analysis showed a 8,21 (q22;q22) translocation and who entered complete remission after one course of chemotherapy. During the post-chemotherapy aplastic phase blood-derived hemopoietic circulating system cells were collected by continuous flow aphereses. Chromosomal analysis on the collected cells and on colonies (CFU-GM grown in agar) showed the same anomaly as was present at diagnosis in about 30% of those analyzed. This confirms the persistence of the malignant clone in the early phase of the clinical remission in acute nonlymphocytic leukemia.

Original languageEnglish
Pages (from-to)210-212
Number of pages3
JournalActa Haematologica
Issue number4
Publication statusPublished - 1989



  • complete remission
  • leukemia acute nonlymphocytic
  • peripheral blood stem cells

ASJC Scopus subject areas

  • Hematology

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