We describe a patient with acute nonlymphocytic leukemia in whom chromosomal analysis showed a 8,21 (q22;q22) translocation and who entered complete remission after one course of chemotherapy. During the post-chemotherapy aplastic phase blood-derived hemopoietic circulating system cells were collected by continuous flow aphereses. Chromosomal analysis on the collected cells and on colonies (CFU-GM grown in agar) showed the same anomaly as was present at diagnosis in about 30% of those analyzed. This confirms the persistence of the malignant clone in the early phase of the clinical remission in acute nonlymphocytic leukemia.
|Number of pages||3|
|Publication status||Published - 1989|
- complete remission
- leukemia acute nonlymphocytic
- peripheral blood stem cells
ASJC Scopus subject areas