Acute Nonspecific Mesenteric Lymphadenitis: More Than "no Need for Surgery"

Rossana Helbling, Elisa Conficconi, Marina Wyttenbach, Cecilia Benetti, Giacomo D. Simonetti, Mario G. Bianchetti, Flurim Hamitaga, Sebastiano A.G. Lava, Emilio F. Fossali, Gregorio P. Milani

Research output: Contribution to journalReview article


Acute nonspecific, or primary, mesenteric lymphadenitis is a self-limiting inflammatory condition affecting the mesenteric lymph nodes, whose presentation mimics appendicitis or intussusception. It typically occurs in children, adolescents, and young adults. White blood count and C-reactive protein are of limited usefulness in distinguishing between patients with and without mesenteric lymphadenitis. Ultrasonography, the mainstay of diagnosis, discloses 3 or more mesenteric lymph nodes with a short-axis diameter of 8 mm or more without any identifiable underlying inflammatory process. Once the diagnosis is established, supportive care including hydration and pain medication is advised. Furthermore, it is crucial to reassure patients and families by explaining the condition and stating that affected patients recover completely without residuals within 2-4 weeks.

Original languageEnglish
Article number9784565
JournalBioMed Research International
Publication statusPublished - 2017


ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Helbling, R., Conficconi, E., Wyttenbach, M., Benetti, C., Simonetti, G. D., Bianchetti, M. G., Hamitaga, F., Lava, S. A. G., Fossali, E. F., & Milani, G. P. (2017). Acute Nonspecific Mesenteric Lymphadenitis: More Than "no Need for Surgery". BioMed Research International, 2017, [9784565].