Acute postsurgical pain in orthopedic surgery: A comparison of sodium naproxen and pentazocine in several analgelsic protocols

S. Lari, A. Coli, R. Mattioli, B. Borghi, G. Fabbri, G. Urso

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Fifty patients undergoing orthopedic surgery were randomized into five groups of ten patients each, treated according to different protocols of postsurgical analgesia. At the end of surgery, one group of patients (PP) received pentazocine (30 mg intramuscularly [IM)]; the same dose was administered after 12 hours. A second (PN) and third group (NP) received 30 mg of pentazocine or 275 mg of sodium naproxen, respectively, at the same time intervals: the order of the administrations was inverted for the two groups in order to verify the efficacy of the association and any influence due to the differing chronology of administration of the drugs. A fourth group of patients (NN) was treated at the same time intervals with sodium naproxen alone at a dose of 275 mg for each IM administration. Finally, a fifth group of patients (ANN) received, in addition to the treatment of the fourth group, a single administration of 2 mg of haloperidol. Based on visual and descriptive scales for algometric measurements, the results showed significant differences in analgesic activity for the five treatments. Pentazocine alone achieved the least satisfactory results and when associated with other substances, a higher incidence of side effects. The association of pentazocine and sodium naproxen did not appear to offer particular advantages compared with sodium naproxen alone. The best results were obtained in the group that received haloperidol in addition to the first dose of sodium naproxen. The central action of the neuroleptic drug is capable of controlling the emotional component of pain and positively completes the pharmacological effects of the nonsteroidal anti-inflammatory drugs.

Original languageEnglish
Pages (from-to)689-697
Number of pages9
JournalCurrent Therapeutic Research
Issue number4
Publication statusPublished - 1988

ASJC Scopus subject areas

  • Medicine(all)


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