Acute premature constriction of the ductus arteriosus after maternal self-medication with nimesulide

Federico Prefumo, Maurizio Marasini, Pierangela De Biasio, Pier Luigi Venturini

Research output: Contribution to journalArticle


Objective: To describe clinical findings in a case of premature ductal constriction associated with maternal use of nimesulide, a cyclo-oxygenase type-2 inhibitor. Methods: Case report. Results: A mother self-administered nimesulide at 39 weeks of gestation due to lower back pain. Less than 24 h later premature ductal constriction was diagnosed by echocardiography following a suspicious fetal heart rate recording with baseline tachycardia and absent accelerations. Conclusion: In a term pregnancy, nimesulide administration can rapidly cause premature ductal constriction. This condition may induce abnormalities in the fetal heart rate trace.

Original languageEnglish
Pages (from-to)35-38
Number of pages4
JournalFetal Diagnosis and Therapy
Issue number1
Publication statusPublished - Jul 2008



  • Ductus arteriosus
  • Fetal heart rate
  • Nimesulide
  • Premature ductal constriction
  • Ultrasound

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Pediatrics, Perinatology, and Child Health

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