Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes

M. Lafage-Pochitaloff, M. Alcalay, V. Brunel, L. Longo, D. Sainty, J. Simonetti, F. Birg, P. G. Pelicci

Research output: Contribution to journalArticlepeer-review

Abstract

Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis.

Original languageEnglish
Pages (from-to)1169-1174
Number of pages6
JournalBlood
Volume85
Issue number5
Publication statusPublished - 1995

ASJC Scopus subject areas

  • Hematology

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