Acute promyelocytic leukemia: Results of therapy and analysis of 13 cases1

Donatella Ruggero, Michele Baccarani, Anna Guarini, Luigi Gugliotta, Marco Gobbi, Paolo Ricci, Alfonso Zaccaria, Francesco Lauria, Ivana Tomasini, Mauro Fiacchini, Maria Alessandra Santucci, Sante Tura

Research output: Contribution to journalArticle

Abstract

Acute promyelocytic leukemia (APL) was diagnosed in 13 of 84 adult patients (15.4°/«) with acute myeloid leukemia (AML) first admitted between 1972 and 1976. All patients had clinical and/or laboratory evidence of defibrination syndrome. Four patients died of cerebral hemorrhage within 2 days of admission. Two patients died of generalized infection on days 7, and 16, respectively, after admission. The remaining 7 patients (54°/o) underwent complete remission (CR) with daunomycin, arabinosyl cytosine, and adriamycin. All patients received massive platelet transfusion, no heparin, and no granulocyte transfusion. CR was more frequent in patients with a very low blast cell count and a fibrinogen level higher than 100 mg/ 100 ml. Median survival of these seven CR patients with APL is similar (15 months) to that of CR patients with other types of AML treated at the same institution during the same period.

Original languageEnglish
Pages (from-to)108-119
Number of pages12
JournalActa Haematologica
Volume58
Issue number2
DOIs
Publication statusPublished - 1977

Keywords

  • Acute myeloid leukemia
  • Acute promyelocytic leukemia
  • Daunomycin Platelet transfusion

ASJC Scopus subject areas

  • Hematology

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    Ruggero, D., Baccarani, M., Guarini, A., Gugliotta, L., Gobbi, M., Ricci, P., Zaccaria, A., Lauria, F., Tomasini, I., Fiacchini, M., Santucci, M. A., & Tura, S. (1977). Acute promyelocytic leukemia: Results of therapy and analysis of 13 cases1. Acta Haematologica, 58(2), 108-119. https://doi.org/10.1159/000207816