Acute pulmonary embolism: External validation of an integrated risk stratification model

Cecilia Becattini, Franco Casazza, Chiara Forgione, Fernando Porro, Bianca Maria Fadin, Alessandra Stucchi, Alessandra Lignani, Luca Conte, Ferdinando Imperadore, Amedeo Bongarzoni, Giancarlo Agnelli

Research output: Contribution to journalArticlepeer-review

Abstract

Background: In hemodynamically stable patients with acute pulmonary embolism, risk stratification is essential to drive clinical management. In these patients, risk stratification for in-hospital adverse outcomes based on markers of right ventricular dysfunction and injury has been proposed. Methods: The aim of this study was to validate a model based on the incremental prognostic value of right ventricular dysfunction and injury in hemodynamically stable patients with acute pulmonary embolism. Patients from the prospective Italian Pulmonary Embolism Registry were included in the study. Study outcomes were in-hospital death and the composite of in-hospital death or clinical deterioration. Results: Among 1,515 hemodynamically stable patients, 869 had both echocardiography and troponin assessments. The risk for in-hospital death or clinical deterioration was higher in patients with right ventricular dysfunction and elevated troponin level (8.8%; hazard ratio [HR], 14.2 [95% CI, 1.94-104.16]; P

Original languageEnglish
Pages (from-to)1539-1545
Number of pages7
JournalChest
Volume144
Issue number5
DOIs
Publication statusPublished - Nov 2013

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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