Acute radiation dermatitis in breast cancer: Topical therapy with vitamin E acetate in lipophilic gel base

S. Martella, M. Rietjens, V. Lohsiriwat, R. Lazzari, A. Vavassori, B. A. Jereczek, V. Lazzati, M. C. Leonardi, J. Y. Petit

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Radiotherapy can cause adverse skin reactions over the course of their treatment. Currently, management is based on several tropical products although there is no gold-standard approach to prevention and management of radiation toxicity. Method: We report our experience of vitamin E acetate in the treatment of radiation dermatitis in breast cancer patients who experienced grade 4 side effects (according to Radiation Therapy Oncology Group criteria). Results: Clinical management consisted of oral antibiotics and local application of vitamin E acetate and local escarectomy. All of the patients achieved complete re-epithelialization within 40 days. Conclusion: Skin ulceration and necrosis post-radiation may interrupt oncological treatment in breast cancer patients. In acute radiodermatitis with skin necrosis, we propose the use of oral antibiotics together with escarectomy and the application of vitamin E acetate to facilitate the healing process in order to minimize the interruption to the oncological treatment.

Original languageEnglish
Article number190
Journalecancermedicalscience
Volume4
Issue number1
DOIs
Publication statusPublished - Dec 23 2010

Keywords

  • Breast cancer
  • Radiation dermatitis
  • Vitamin E

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Acute radiation dermatitis in breast cancer: Topical therapy with vitamin E acetate in lipophilic gel base'. Together they form a unique fingerprint.

Cite this