Acute renal failure in idiopathic nephrotic syndrome

E. Imbasciati, C. Ponticelli, N. Case, P. Altieri, F. Bolasco, M. J. Mihatsch, H. U. Zollinger

Research output: Contribution to journalArticle

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Abstract

In 4 adults with idiopathic nephrotic syndrome an acute renal failure with prolonged anuria has been observed. At renal histology 1 patient showed minimal glomerular changes and 3 showed focal glomerulosclerosis. No vascular abnormalities were seen. In all cases severe tubular lesions with casts and cell debris in the lumina were observed. In 2 patients renal function improved after 3 and 6 months, respectively; the remaining 2 died after several months from the onset of acute renal failure being still anuric. Although the pathogenesis of this complication is unknown, tubular obstruction by proteinaceous casts and vasoconstriction may play an important role. The prognosis of this complication is severe, but the possibility of spontaneous recovery even after protracted anuria cannot be ruled out.

Original languageEnglish
Pages (from-to)186-191
Number of pages6
JournalNephron
Volume28
Issue number4
Publication statusPublished - 1981

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Anuria
Acute Kidney Injury
Kidney
Focal Segmental Glomerulosclerosis
Vasoconstriction
Blood Vessels
Histology
Congenital Nephrosis

ASJC Scopus subject areas

  • Nephrology

Cite this

Imbasciati, E., Ponticelli, C., Case, N., Altieri, P., Bolasco, F., Mihatsch, M. J., & Zollinger, H. U. (1981). Acute renal failure in idiopathic nephrotic syndrome. Nephron, 28(4), 186-191.

Acute renal failure in idiopathic nephrotic syndrome. / Imbasciati, E.; Ponticelli, C.; Case, N.; Altieri, P.; Bolasco, F.; Mihatsch, M. J.; Zollinger, H. U.

In: Nephron, Vol. 28, No. 4, 1981, p. 186-191.

Research output: Contribution to journalArticle

Imbasciati, E, Ponticelli, C, Case, N, Altieri, P, Bolasco, F, Mihatsch, MJ & Zollinger, HU 1981, 'Acute renal failure in idiopathic nephrotic syndrome', Nephron, vol. 28, no. 4, pp. 186-191.
Imbasciati E, Ponticelli C, Case N, Altieri P, Bolasco F, Mihatsch MJ et al. Acute renal failure in idiopathic nephrotic syndrome. Nephron. 1981;28(4):186-191.
Imbasciati, E. ; Ponticelli, C. ; Case, N. ; Altieri, P. ; Bolasco, F. ; Mihatsch, M. J. ; Zollinger, H. U. / Acute renal failure in idiopathic nephrotic syndrome. In: Nephron. 1981 ; Vol. 28, No. 4. pp. 186-191.
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