TY - JOUR
T1 - Acute respiratory distress syndrome in adenovirus type 4 pneumonia
T2 - A case report
AU - Narra, R.
AU - Bono, Patrizia
AU - Zoccoli, Antonella
AU - Orlandi, Anna
AU - Piconi, S.
AU - Grasselli, G.
AU - Crotti, Stefania
AU - Girello, Alessia
AU - Piralla, Antonio
AU - Baldanti, Fausto
AU - Lunghi, Giovanna
PY - 2016/8/1
Y1 - 2016/8/1
N2 - Human adenoviruses (HAdVs) cause a wide spectrum of clinical syndromes, depending on species and types, from mild respiratory infections to deadly pneumonia: in particular, severe infections occur in immunocompromised patients. In this report, we describe the case of a 36 years-old woman admitted to our intensive care unit (ICU) with severe respiratory distress syndrome caused by adenovirus pneumonia, that required invasive respiratory support (mechanical ventilation and extracorporeal membrane oxygenation). Molecular assays detected the virus in respiratory and plasma specimen and sequencing procedure identified HAdV type 4. Patient improved after cidofovir administration. Leukopenia and subsequent bacterial infection occurred, but the patient recovered completely and was discharged from the hospital after 54 days.
AB - Human adenoviruses (HAdVs) cause a wide spectrum of clinical syndromes, depending on species and types, from mild respiratory infections to deadly pneumonia: in particular, severe infections occur in immunocompromised patients. In this report, we describe the case of a 36 years-old woman admitted to our intensive care unit (ICU) with severe respiratory distress syndrome caused by adenovirus pneumonia, that required invasive respiratory support (mechanical ventilation and extracorporeal membrane oxygenation). Molecular assays detected the virus in respiratory and plasma specimen and sequencing procedure identified HAdV type 4. Patient improved after cidofovir administration. Leukopenia and subsequent bacterial infection occurred, but the patient recovered completely and was discharged from the hospital after 54 days.
KW - Adenoviral pneumonia
KW - Adenovirus
KW - Infectious disease
KW - Intensive care unit
KW - Polymerase chain reaction (PCR)
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U2 - 10.1016/j.jcv.2016.06.005
DO - 10.1016/j.jcv.2016.06.005
M3 - Article
VL - 81
SP - 78
EP - 81
JO - Journal of Clinical Virology
JF - Journal of Clinical Virology
SN - 1386-6532
ER -