Abstract
Platelet sensitivity to PGI2 and platelet PGI2 receptors were investigated in eight subjects with peripheral artery disease (stage IV according to Fontaine) treated for 14 consecutive days with six hour iv infusion of Iloprost (Schering, FRG) 2 ng/Kg/min. Platelet studies were performed on the 1st, the 2nd, the 7th and the 14th day of therapy, immediately before infusion (between 8.00 and 9.00 a.m.), at the end and 6 and 18 hours (the following morning) after the end of the infusion. Platelet sensitivity to PGI2 was assessed by determining the PGI2 inhibitory dose 50(ID 50) on platelet aggregation induced by 5 μM ADP. PGI2 platelet receptors were investigated by a direct radioligand binding assay. PGI2 ID 50 after the infusion was significantly higher than that at baseline(p
Original language | English |
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Pages (from-to) | 663-669 |
Number of pages | 7 |
Journal | Thrombosis Research |
Volume | 48 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 15 1987 |
Keywords
- down-regulation
- Iloprost
- prostacyclin
- receptor
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Hematology