Abstract

Background: During the 2013-2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. Case presentation: In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10days and indomethacin for 2months. No evidence of recurrence is reported. Conclusions: A febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.

Original languageEnglish
Article number597
JournalBMC Infectious Diseases
Volume17
Issue number1
DOIs
Publication statusPublished - Aug 30 2017

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Ebola Hemorrhagic Fever
Rhabdomyolysis
Pericardial Effusion
Ebolavirus
Adrenal Cortex Hormones
Fever
Male Nurses
Sierra Leone
Western Africa
Indomethacin
Italy
Monoclonal Antibodies
Delivery of Health Care
Recurrence

Keywords

  • Ebola Virus Disease
  • Pericardial effusion
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Infectious Diseases

Cite this

@article{97a8e4deacc64927a44fa3e575b87321,
title = "Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease: A case report",
abstract = "Background: During the 2013-2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. Case presentation: In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10days and indomethacin for 2months. No evidence of recurrence is reported. Conclusions: A febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.",
keywords = "Ebola Virus Disease, Pericardial effusion, Rhabdomyolysis",
author = "Emanuele Nicastri and Nicola Petrosillo and Gianluigi Biava and Giuseppe Ippolito and Nazario Bevilacqua and Evangelo Boumis and Pierangelo Chinello and Stefania Cicalini and Angela Corpolongo and Vincenzo Galati and Andrea Mariano and Silvia Rosati and Fabrizio Taglietti and Laura Vincenzi and Mario Antonini and Ilaria Caravella and Gabriele Garotto and Luisa Marchioni and Micaela Maritti and Pietro Balestra and Martina Ricottini and Rizzi, {Elisa Busi} and Capobianchi, {Maria Rosaria} and {di Caro}, Antonino and Concetta Castilletti and Licia Bordi and Eleonora Lalle and Mirella Biava and Silvia Meschi and Daniele Lapa and Patrizia Marsella and Francesca Colavita and Roberta Chiappini and Antonio Mazzarelli and Serena Quartu and Chiara Agrati and Fabrizio Carletti and Federica Forbici and Valli, {Maria Beatrice} and Isabella Abbate and Alessandra Amendola and Garbuglia, {Anna Rosa} and Paglia, {Maria Grazia} and Eugenio Bordi and Lauria, {Francesco Nicola} and Vincenzo Puro and Antonella Petrecchia and Marco Gentile and Silvia Pittalis and Lorena Martini and Fusco, {Francesco Maria} and Simone Lanini and Andrea Antinori and {INMI's Ebola Team}",
year = "2017",
month = "8",
day = "30",
doi = "10.1186/s12879-017-2689-x",
language = "English",
volume = "17",
journal = "BMC Infectious Diseases",
issn = "1471-2334",
publisher = "BioMed Central Ltd.",
number = "1",

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TY - JOUR

T1 - Acute rhabdomyolysis and delayed pericardial effusion in an Italian patient with Ebola virus disease

T2 - A case report

AU - Nicastri, Emanuele

AU - Petrosillo, Nicola

AU - Biava, Gianluigi

AU - Ippolito, Giuseppe

AU - Bevilacqua, Nazario

AU - Boumis, Evangelo

AU - Chinello, Pierangelo

AU - Cicalini, Stefania

AU - Corpolongo, Angela

AU - Galati, Vincenzo

AU - Mariano, Andrea

AU - Rosati, Silvia

AU - Taglietti, Fabrizio

AU - Vincenzi, Laura

AU - Antonini, Mario

AU - Caravella, Ilaria

AU - Garotto, Gabriele

AU - Marchioni, Luisa

AU - Maritti, Micaela

AU - Balestra, Pietro

AU - Ricottini, Martina

AU - Rizzi, Elisa Busi

AU - Capobianchi, Maria Rosaria

AU - di Caro, Antonino

AU - Castilletti, Concetta

AU - Bordi, Licia

AU - Lalle, Eleonora

AU - Biava, Mirella

AU - Meschi, Silvia

AU - Lapa, Daniele

AU - Marsella, Patrizia

AU - Colavita, Francesca

AU - Chiappini, Roberta

AU - Mazzarelli, Antonio

AU - Quartu, Serena

AU - Agrati, Chiara

AU - Carletti, Fabrizio

AU - Forbici, Federica

AU - Valli, Maria Beatrice

AU - Abbate, Isabella

AU - Amendola, Alessandra

AU - Garbuglia, Anna Rosa

AU - Paglia, Maria Grazia

AU - Bordi, Eugenio

AU - Lauria, Francesco Nicola

AU - Puro, Vincenzo

AU - Petrecchia, Antonella

AU - Gentile, Marco

AU - Pittalis, Silvia

AU - Martini, Lorena

AU - Fusco, Francesco Maria

AU - Lanini, Simone

AU - Antinori, Andrea

AU - INMI's Ebola Team

PY - 2017/8/30

Y1 - 2017/8/30

N2 - Background: During the 2013-2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. Case presentation: In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10days and indomethacin for 2months. No evidence of recurrence is reported. Conclusions: A febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.

AB - Background: During the 2013-2016 West Africa Ebola virus disease (EVD) epidemic, some EVD patients, mostly health care workers, were evacuated to Europe and the USA. Case presentation: In May 2015, a 37-year old male nurse contracted Ebola virus disease in Sierra Leone. After Ebola virus detection in plasma, he was medically-evacuated to Italy. At admission, rhabdomyolysis was clinically and laboratory-diagnosed and was treated with aggressive hydration, oral favipiravir and intravenous investigational monoclonal antibodies against Ebola virus. The recovery clinical phase was complicated by a febrile thrombocytopenic syndrome with pericardial effusion treated with corticosteroids for 10days and indomethacin for 2months. No evidence of recurrence is reported. Conclusions: A febrile thrombocytopenic syndrome with pericardial effusion during the recovery phase of EVD appears to be uncommon. Clinical improvement with corticosteroid treatment suggests that an immune-mediated mechanism contributed to the pericardial effusion.

KW - Ebola Virus Disease

KW - Pericardial effusion

KW - Rhabdomyolysis

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U2 - 10.1186/s12879-017-2689-x

DO - 10.1186/s12879-017-2689-x

M3 - Article

AN - SCOPUS:85028548573

VL - 17

JO - BMC Infectious Diseases

JF - BMC Infectious Diseases

SN - 1471-2334

IS - 1

M1 - 597

ER -