TY - JOUR
T1 - Acute rheumatic fever prophylaxis in high-income countries: Clinical observations from an Italian multicentre retrospective study
AU - Taddio, Andrea
AU - Pillon, Roberto
AU - Pastore, Serena
AU - Monasta, Lorenzo
AU - Tommasini, Alberto
AU - Di Battista, Caterina
AU - Mascheroni, Elisabetta
AU - Berton, Emanuela
AU - Maggio, Maria Cristina
AU - Simonini, Gabriele
AU - Breda, Luciana
AU - Cimaz, Rolando
AU - Marafon, Denise Pires
AU - Meli, Lidia
AU - Bracaglia, Claudia
AU - De Benedetti, Fabrizio
AU - Ventura, Alessandro
N1 - Publisher Copyright:
© Copyright CliniCal and ExpErimEntal rhEumatology 2020.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/1
Y1 - 2020/9/1
N2 - Objective The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of rheumatic heart disease (RHD) in a cohort of Italian patients with acute rheumatic fever (ARF). Methods This is a multicentre retrospective study. The patients were divided into two groups by the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results Two-hundred and ninety patients were enrolled (137 females; 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients manifested RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p=0.001), but it was not related to secondary prophylaxis adherence (p=NS). No association between prophylaxis adherence and ARF recurrence was found (p=NS) nor between ARF recurrence and RHD at the end of follow-up (p=NS). Conclusion Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm our data in a larger population.
AB - Objective The aim of the study is to evaluate the compliance rate to secondary prophylaxis and the presence of rheumatic heart disease (RHD) in a cohort of Italian patients with acute rheumatic fever (ARF). Methods This is a multicentre retrospective study. The patients were divided into two groups by the presence or absence at last follow-up of RHD. Clinical features, ARF recurrences and the rate of compliance to secondary prophylaxis were evaluated. Results Two-hundred and ninety patients were enrolled (137 females; 153 males). Carditis at onset was present in 244 patients (84.7%). At the end of follow-up, 173 patients manifested RHD. Adherence to secondary prophylaxis was low in 26% of patients. The presence of RHD at follow-up was associated with the presence of carditis and its severity at onset (p=0.001), but it was not related to secondary prophylaxis adherence (p=NS). No association between prophylaxis adherence and ARF recurrence was found (p=NS) nor between ARF recurrence and RHD at the end of follow-up (p=NS). Conclusion Poor adherence to secondary prophylaxis does not seem to be associated with increased risk of RHD in developed countries. Further studies are needed to confirm our data in a larger population.
KW - Acute rheumatic fever
KW - Carditis
KW - Compliance
KW - Prophylaxis
KW - Rheumatic heart disease
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M3 - Article
C2 - 31969217
AN - SCOPUS:85092603442
VL - 38
SP - 1016
EP - 1020
JO - Clinical and Experimental Rheumatology
JF - Clinical and Experimental Rheumatology
SN - 0392-856X
IS - 5
ER -