Acute scopolamine treatment decreases dopamine metabolism in rat hippocampus and frontal cortex

Maurizio Memo, Cristina Missale, Luca Trivelli, Pier Franco Spano

Research output: Contribution to journalArticle

Abstract

The aim of the present study was to correlate the impairment of cognitive function induced by scopolamine with the activity of dopaminergic synapses in brain areas which are innvervated by mesocotical limbic system (e.g. hippocampus and frontal cortex) or by the mesostriatal system (e.g. striatal and nucleus accumbens). The results indicate that acetylcholine receptor blockade induced by the intraperitoneal injection of 0.5 mg/kg scopolamine resulted in a selective decrease in the content of the dopamine metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA). This effect appeared to be specific for the hippocampus and frontal cortex. Indeed, dopamine turnover in striatum and nucleus accumbens was not affected by scopolamine treatment. The scopolamine-induced decrease of dopamine turnover in both hippocampus and frontal cortex paralleled in terms of both time- and dose-dependence the drug-induced amnesic effects, as measured by a passive avoidance behavioral test.

Original languageEnglish
Pages (from-to)367-370
Number of pages4
JournalEuropean Journal of Pharmacology
Volume149
Issue number3
DOIs
Publication statusPublished - May 10 1988

Keywords

  • Dopamine
  • Meso-striatal system
  • Mesolimbic-cortical system
  • Scopolamine

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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