Acute self-limiting hepatitis C after possible sexual exposure: Sequence analysis of the E-2 region of the infected patient and sexual partner

G. Morsica, G. Sitia, M. T. Bernardi, G. Tambussi, R. Novati, A. De Bona, N. Gianotti, A. Lazzarin

Research output: Contribution to journalArticle

Abstract

We describe a case of symptomatic acute infection with HCV in a woman whose sexual partner had chronic hepatitis C. The patient cleared HCV RNA 8 weeks after the onset of acute hepatitis and was found to be persistently HCV-RNA negative during 90 weeks of follow-up. Part of the E-2 region of HCV was directly sequenced in the patient and her sexual partner. Four local controls with subtype-1a infection and 9 1a isolates obtained from GenBank were analyzed. The average nucleotide divergence between the sequences of the infected patient and her sexual partner was 5.1%, compared with an average nucleotide divergence of 19.4% (range 16.6-21.8%) between the sequences of the patient and those of controls. Comparison of the phylogenetic trees in the partial E-2 region showed that the sequence of the patient was closely related to that of her sexual partner. Our findings suggest that the infection was transmitted to the patient from her sexual partner. The resolution of acute hepatitis C in this case was probably related to the host rather than to intrinsic characteristics of the HCV genome.

Original languageEnglish
Pages (from-to)116-120
Number of pages5
JournalScandinavian Journal of Infectious Diseases
Volume33
Issue number2
DOIs
Publication statusPublished - 2001

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Sexual Partners
Hepatitis C
Sequence Analysis
Nucleotides
Infection
RNA
Nucleic Acid Databases
Chronic Hepatitis C
Hepatitis
Genome

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)

Cite this

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title = "Acute self-limiting hepatitis C after possible sexual exposure: Sequence analysis of the E-2 region of the infected patient and sexual partner",
abstract = "We describe a case of symptomatic acute infection with HCV in a woman whose sexual partner had chronic hepatitis C. The patient cleared HCV RNA 8 weeks after the onset of acute hepatitis and was found to be persistently HCV-RNA negative during 90 weeks of follow-up. Part of the E-2 region of HCV was directly sequenced in the patient and her sexual partner. Four local controls with subtype-1a infection and 9 1a isolates obtained from GenBank were analyzed. The average nucleotide divergence between the sequences of the infected patient and her sexual partner was 5.1{\%}, compared with an average nucleotide divergence of 19.4{\%} (range 16.6-21.8{\%}) between the sequences of the patient and those of controls. Comparison of the phylogenetic trees in the partial E-2 region showed that the sequence of the patient was closely related to that of her sexual partner. Our findings suggest that the infection was transmitted to the patient from her sexual partner. The resolution of acute hepatitis C in this case was probably related to the host rather than to intrinsic characteristics of the HCV genome.",
author = "G. Morsica and G. Sitia and Bernardi, {M. T.} and G. Tambussi and R. Novati and {De Bona}, A. and N. Gianotti and A. Lazzarin",
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AU - Morsica, G.

AU - Sitia, G.

AU - Bernardi, M. T.

AU - Tambussi, G.

AU - Novati, R.

AU - De Bona, A.

AU - Gianotti, N.

AU - Lazzarin, A.

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