Acute skin toxicity management in head and neck cancer patients treated with radiotherapy and chemotherapy or EGFR inhibitors: Literature review and consensus

Elvio G. Russi, Francesco Moretto, Monica Rampino, Marco Benasso, Almalina Bacigalupo, Vitaliana De Sanctis, Gianmauro Numico, Paolo Bossi, Michela Buglione, Antonino Lombardo, Mario Airoldi, Marco C. Merlano, Lisa Licitra, Nerina Denaro, Stefano Pergolizzi, Carmine Pinto, Renè Jean Bensadoun, Giampiero Girolomoni, Johannes A. Langendijk

Research output: Contribution to journalArticlepeer-review

Abstract

The adverse effects of radiation therapy, often integrated with chemotherapy and/or targeted therapies, on the skin include severe acute and chronic dermatitis associated with pain, discomfort, itching, and burning, and may heavily affect patients' quality of life. The management of these skin adverse effects in head and neck cancer patients (HNCPs) are very heterogeneous due to the lack of shared rigorous classification systems and evidence based treatments.A multidisciplinary group of head and neck cancer specialists from Italy met with the aim of reaching a consensus on a clinical definition and management of dermatitis in HNCPs treated with radiotherapy with or without systemic therapies in order to improve skin toxicity management. The Delphi Appropriateness Method was used. External expert reviewers then evaluated the conclusions carefully according to their area of expertise.This paper offers contains seven clusters of statements about the management of dermatitis in HNCPs and a review of recent literature on these topics.

Original languageEnglish
Pages (from-to)167-182
Number of pages16
JournalCritical Reviews in Oncology/Hematology
Volume96
Issue number1
DOIs
Publication statusPublished - Oct 1 2015

Keywords

  • Biodermatitis
  • Cetuximab
  • Chemotherapy
  • EGFRi
  • Head and neck cancer
  • Radiotherapy
  • Skin toxicity

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

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