Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus

F. Fumagalli, L. Madaschi, L. Caffino, G. Marfia, A. M. Di Giulio, G. Racagni, A. Gorio

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Spinal cord injury (SCI) is a devastating event which causes dramatic changes in the everyday life of the patient. We have found that acute SCI reduced BDNF expression selectively in the hippocampus of lesioned rats, a decrease which persists at least 1 week, thus identifying the modulation of the neurotrophin biosynthesis as an important mechanism underlying brain vulnerability to SCI. These data are the first to show that SCI alters hippocampal BDNF expression and identify the neurotrophin as a potential target through which SCI changes brain functions, a notion that might prove useful in understanding the mechanisms underlying brain vulnerability to SCI.

Original languageEnglish
Pages (from-to)936-939
Number of pages4
JournalNeuroscience
Volume159
Issue number3
DOIs
Publication statusPublished - Mar 31 2009

Fingerprint

Spinal Cord Injuries
Hippocampus
Brain
Brain-Derived Neurotrophic Factor
Nerve Growth Factors

Keywords

  • brain
  • FGF-2
  • GAP-43
  • laminectomy
  • lesion
  • neurotrophin

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fumagalli, F., Madaschi, L., Caffino, L., Marfia, G., Di Giulio, A. M., Racagni, G., & Gorio, A. (2009). Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. Neuroscience, 159(3), 936-939. https://doi.org/10.1016/j.neuroscience.2009.01.030

Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. / Fumagalli, F.; Madaschi, L.; Caffino, L.; Marfia, G.; Di Giulio, A. M.; Racagni, G.; Gorio, A.

In: Neuroscience, Vol. 159, No. 3, 31.03.2009, p. 936-939.

Research output: Contribution to journalArticle

Fumagalli, F, Madaschi, L, Caffino, L, Marfia, G, Di Giulio, AM, Racagni, G & Gorio, A 2009, 'Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus', Neuroscience, vol. 159, no. 3, pp. 936-939. https://doi.org/10.1016/j.neuroscience.2009.01.030
Fumagalli F, Madaschi L, Caffino L, Marfia G, Di Giulio AM, Racagni G et al. Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. Neuroscience. 2009 Mar 31;159(3):936-939. https://doi.org/10.1016/j.neuroscience.2009.01.030
Fumagalli, F. ; Madaschi, L. ; Caffino, L. ; Marfia, G. ; Di Giulio, A. M. ; Racagni, G. ; Gorio, A. / Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. In: Neuroscience. 2009 ; Vol. 159, No. 3. pp. 936-939.
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