Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus

F. Fumagalli, L. Madaschi, L. Caffino, G. Marfia, A. M. Di Giulio, G. Racagni, A. Gorio

Research output: Contribution to journalArticle

Abstract

Spinal cord injury (SCI) is a devastating event which causes dramatic changes in the everyday life of the patient. We have found that acute SCI reduced BDNF expression selectively in the hippocampus of lesioned rats, a decrease which persists at least 1 week, thus identifying the modulation of the neurotrophin biosynthesis as an important mechanism underlying brain vulnerability to SCI. These data are the first to show that SCI alters hippocampal BDNF expression and identify the neurotrophin as a potential target through which SCI changes brain functions, a notion that might prove useful in understanding the mechanisms underlying brain vulnerability to SCI.

Original languageEnglish
Pages (from-to)936-939
Number of pages4
JournalNeuroscience
Volume159
Issue number3
DOIs
Publication statusPublished - Mar 31 2009

Keywords

  • brain
  • FGF-2
  • GAP-43
  • laminectomy
  • lesion
  • neurotrophin

ASJC Scopus subject areas

  • Neuroscience(all)

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    Fumagalli, F., Madaschi, L., Caffino, L., Marfia, G., Di Giulio, A. M., Racagni, G., & Gorio, A. (2009). Acute spinal cord injury reduces brain derived neurotrohic factor expression in rat hippocampus. Neuroscience, 159(3), 936-939. https://doi.org/10.1016/j.neuroscience.2009.01.030