Acute T-cell activation is detectable in unstable angina

Gian Gastone Neri Serneri; Domenico Prisco; Francesca Martini; Anna Maria Gori; Tamara Brunelli; Loredana Poggesi; Carlo Rostagno; Gian Franco Gensini; Rosanna Abbate

Acute T-cell activation is detectable in unstable angina

Gian Gastone Neri Serneri, Domenico Prisco, Francesca Martini, Anna Maria Gori, Tamara Brunelli, Loredana Poggesi, Carlo Rostagno, Gian Franco Gensini, Rosanna Abbate

Fondazione Don Carlo Gnocchi Onlus

Research output: Contribution to journal › Article

Abstract

Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P

Original language	English
Pages (from-to)	1806-1812
Number of pages	7
Journal	Circulation
Volume	95
Issue number	7
Publication status	Published - Apr 1 1997

Keywords

angina
coronary disease
immune system
interleukins
lymphocytes

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

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title = "Acute T-cell activation is detectable in unstable angina",

abstract = "Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P",

keywords = "angina, coronary disease, immune system, interleukins, lymphocytes",

author = "{Neri Serneri}, {Gian Gastone} and Domenico Prisco and Francesca Martini and Gori, {Anna Maria} and Tamara Brunelli and Loredana Poggesi and Carlo Rostagno and Gensini, {Gian Franco} and Rosanna Abbate",

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T1 - Acute T-cell activation is detectable in unstable angina

AU - Neri Serneri, Gian Gastone

AU - Prisco, Domenico

AU - Martini, Francesca

AU - Gori, Anna Maria

AU - Brunelli, Tamara

AU - Poggesi, Loredana

AU - Rostagno, Carlo

AU - Gensini, Gian Franco

AU - Abbate, Rosanna

PY - 1997/4/1

Y1 - 1997/4/1

N2 - Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P

AB - Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P

KW - angina

KW - coronary disease

KW - immune system

KW - interleukins

KW - lymphocytes

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