Abstract
Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P
| Original language | English |
|---|---|
| Pages (from-to) | 1806-1812 |
| Number of pages | 7 |
| Journal | Circulation |
| Volume | 95 |
| Issue number | 7 |
| Publication status | Published - Apr 1 1997 |
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Keywords
- angina
- coronary disease
- immune system
- interleukins
- lymphocytes
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Acute T-cell activation is detectable in unstable angina. / Neri Serneri, Gian Gastone; Prisco, Domenico; Martini, Francesca; Gori, Anna Maria; Brunelli, Tamara; Poggesi, Loredana; Rostagno, Carlo; Gensini, Gian Franco; Abbate, Rosanna.
In: Circulation, Vol. 95, No. 7, 01.04.1997, p. 1806-1812.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute T-cell activation is detectable in unstable angina
AU - Neri Serneri, Gian Gastone
AU - Prisco, Domenico
AU - Martini, Francesca
AU - Gori, Anna Maria
AU - Brunelli, Tamara
AU - Poggesi, Loredana
AU - Rostagno, Carlo
AU - Gensini, Gian Franco
AU - Abbate, Rosanna
PY - 1997/4/1
Y1 - 1997/4/1
N2 - Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P
AB - Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P
KW - angina
KW - coronary disease
KW - immune system
KW - interleukins
KW - lymphocytes
UR - http://www.scopus.com/inward/record.url?scp=0342378103&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0342378103&partnerID=8YFLogxK
M3 - Article
C2 - 9107167
AN - SCOPUS:0342378103
VL - 95
SP - 1806
EP - 1812
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 7
ER -