Acute T-cell activation is detectable in unstable angina

Gian Gastone Neri Serneri, Domenico Prisco, Francesca Martini, Anna Maria Gori, Tamara Brunelli, Loredana Poggesi, Carlo Rostagno, Gian Franco Gensini, Rosanna Abbate

Research output: Contribution to journalArticle

Abstract

Background: Recent studies suggest a role for inflammation in the pathophysiology of unstable angina. This study was designed to investigate whether circulating lymphocytes are involved in the inflammatory reaction associated with the episodes of unstable angina. Methods and Results: Twenty- nine patients with proven unstable angina, 36 with stable angina, and 30 healthy subjects were studied. Both early and short-lived (interleukin-2 receptor [IL-2R], α-chain CD25, and transferrin receptor CD71) and late antigen (HLA-DR) expression were investigated by flow cytometric analysis. Soluble IL-2R (slL-2R) was also measured in plasma by ELISA. Lymphocyte activation was studied at day I of hospital admission and after 7, 15, 30, 60, and 90 days. In patients with unstable angina, the number of HLA-DR+ CD3 lymphocytes and levels of sIL-2R were higher (P

Original languageEnglish
Pages (from-to)1806-1812
Number of pages7
JournalCirculation
Volume95
Issue number7
Publication statusPublished - Apr 1 1997

Keywords

  • angina
  • coronary disease
  • immune system
  • interleukins
  • lymphocytes

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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