Acute type B hepatitis in parenteral drug-addicts (PDA): prognostic value of circulating HBsAg/IgM complexes.

F. Caredda, R. De Franchis, A. D'Arminio Monforte, M. Vecchi, F. Antoniozzi, E. Rossi, M. Primignani, M. Moroni

Research output: Contribution to journalArticlepeer-review

Abstract

Fifty-three parenteral drug-addicts with acute viral hepatitis type B were tested by a solid-phase radioimmunoassay for circulating HBsAg/IgM complexes in the acute phase and in the follow-up. Among the 47 recovered patients HBsAg/IgM complexes were either absent from the onset of the disease, or disappeared from serum within 4 weeks of admission, long before HBsAg had cleared or serum alanine aminotransferase has returned to normal. On the contrary, HBsAg/IgM complexes persisted indefinitely among the 6 patients who developed a chronic HBsAg-positive hepatitis. These results indicate that sequential serum testing for HBsAg/IgM complexes might be of value in predicting the long-term outcome of acute type B hepatitis of parenteral drug-addicts.

Original languageEnglish
Pages (from-to)496-498
Number of pages3
JournalBollettino dell'Istituto Sieroterapico Milanese
Volume63
Issue number6
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Immunology

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