Acute upper gastrointestinal bleeding in patients with AIDS: A relatively uncommon condition associated with reduced survival

F. Parente, M. Cernuschi, L. Valsecchi, G. Rizzardini, M. Musicco, A. Lazzarin, G. Bianchi Porro

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Abstract

To determine the cumulative incidence of acute upper gastrointestinal bleeding and its effect upon survival in patients with AIDS, 453 consecutive AIDS patients diagnosed in our hospital between June 1985 and March 1989 were foliowed for a median period of six months (maximum 42 months). The cumulative probability of acute gastrointestinal bleeding was 3% at six months and 6% at 14 months. This event was associated with significantly reduced survival. Independent risk factors for bleeding were: severe thrombocytopenia at the time of diagnosis and non-Hodgkin's lymphoma as the first clinical manifestation of AIDS. The potential causes of bleeding were investigated in all cases by emergency endoscopy or by necropsy examination in those patients whose clinical condition precluded the procedure. In nine of 15 patients, bleeding was due to lesions specifically associated with AIDS, but in the remainder the source of bleeding was not a direct consequence of HIV infection. We conclude that acute upper gastrointestinal bleeding rarely complicates the course of AIDS, but its occurrence is associated with decreased survival. As many of the causes are potentially treatable, a complete diagnostic approach is indicated in these patients, except those who are terminally ill.

Original languageEnglish
Pages (from-to)987-990
Number of pages4
JournalGut
Volume32
Issue number9
DOIs
Publication statusPublished - 1991

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Acquired Immunodeficiency Syndrome
Hemorrhage
Survival
Terminally Ill
Thrombocytopenia
Non-Hodgkin's Lymphoma
Endoscopy
HIV Infections
Emergencies
Incidence

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Gastroenterology

Cite this

Parente, F., Cernuschi, M., Valsecchi, L., Rizzardini, G., Musicco, M., Lazzarin, A., & Bianchi Porro, G. (1991). Acute upper gastrointestinal bleeding in patients with AIDS: A relatively uncommon condition associated with reduced survival. Gut, 32(9), 987-990. https://doi.org/10.1136/gut.32.9.987

Acute upper gastrointestinal bleeding in patients with AIDS : A relatively uncommon condition associated with reduced survival. / Parente, F.; Cernuschi, M.; Valsecchi, L.; Rizzardini, G.; Musicco, M.; Lazzarin, A.; Bianchi Porro, G.

In: Gut, Vol. 32, No. 9, 1991, p. 987-990.

Research output: Contribution to journalArticle

Parente, F, Cernuschi, M, Valsecchi, L, Rizzardini, G, Musicco, M, Lazzarin, A & Bianchi Porro, G 1991, 'Acute upper gastrointestinal bleeding in patients with AIDS: A relatively uncommon condition associated with reduced survival', Gut, vol. 32, no. 9, pp. 987-990. https://doi.org/10.1136/gut.32.9.987
Parente, F. ; Cernuschi, M. ; Valsecchi, L. ; Rizzardini, G. ; Musicco, M. ; Lazzarin, A. ; Bianchi Porro, G. / Acute upper gastrointestinal bleeding in patients with AIDS : A relatively uncommon condition associated with reduced survival. In: Gut. 1991 ; Vol. 32, No. 9. pp. 987-990.
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