Acyclovir resistance/susceptibility in herpes simplex virus type 2 sequential isolates from an AIDS patient

Francesca Bevilacqua, Alessandro Marcello, Marco Toni, Maurizio Zavattoni, Marco Cusini, Roberto Zerboni, Giuseppe Gerna, Giorgio Palú

Research output: Contribution to journalArticle

Abstract

The biological characterization of a number of sequential herpes simplex virus type 2 (HSV-2) isolates obtained from an AIDS patient undergoing sequential courses of antiviral treatment due to an extended mucocuta-neous genital lesion is reported. Resistance to acyclovir (ACV) and related compounds was linked to a thymidine kinase-deficient (TK) phenotype. After ACV discontinuation and a course of treatment with foscarnet, a new isolate was recovered, characterized by loss of the ACV-resistant trait and production of a functional TK enzyme. Data presented stress the need for monitoring chemosensitivity of HSV isolates in AIDS patients while suggesting that for better control of the infection, these patients should benefit from alternative treatments with drugs aimed at different viral targets.

Original languageEnglish
Pages (from-to)967-969
Number of pages3
JournalJournal of Acquired Immune Deficiency Syndromes
Volume4
Issue number10
Publication statusPublished - 1991

Keywords

  • Acyclovir resistance
  • Herpesvi-ruses

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Immunology and Allergy
  • Virology

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