Adaptations of striatal endocannabinoid system during stress

Silvia Rossi, Valentina De Chiara, Alessandra Musella, Giorgia Mataluni, Lucia Sacchetti, Giorgio Bernardi, Alessandro Usiello, Diego Centonze

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The endocannabinoid system (ECS) plays a fundamental role in the regulation of synaptic transmission. Exposure to stressful events triggers synaptic adaptations in many brain areas. The activity of the ECS in stress-responsive neural circuits suggests that it may be involved in the behavioral responses and synaptic effects typical of stress. In this review, we discuss evidence demonstrating that striatal ECS is modulated by stress. Chronic stress exposure alters endocannabinoid levels, cannabinoid CB1 receptor binding and cannabinoid CB1 receptor-mediated control of inhibitory synaptic transmission in the striatum. Recent studies have shown that impairment of endocannabinoid signalling is associated with inability to adapt to chronic stress and to the development of maladaptive behaviors. The ECS represents a novel potential pharmacological target to treat stress-associated neuropsychiatric conditions.

Original languageEnglish
Pages (from-to)178-184
Number of pages7
JournalMolecular Neurobiology
Volume39
Issue number3
DOIs
Publication statusPublished - Jun 2009

Fingerprint

Corpus Striatum
Endocannabinoids
Cannabinoid Receptor CB1
Synaptic Transmission
Pharmacology
Brain

Keywords

  • Anxiety
  • Cocaine
  • Depression
  • FAAH
  • Glucocorticoids
  • Natural reward

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Adaptations of striatal endocannabinoid system during stress. / Rossi, Silvia; De Chiara, Valentina; Musella, Alessandra; Mataluni, Giorgia; Sacchetti, Lucia; Bernardi, Giorgio; Usiello, Alessandro; Centonze, Diego.

In: Molecular Neurobiology, Vol. 39, No. 3, 06.2009, p. 178-184.

Research output: Contribution to journalArticle

Rossi, S, De Chiara, V, Musella, A, Mataluni, G, Sacchetti, L, Bernardi, G, Usiello, A & Centonze, D 2009, 'Adaptations of striatal endocannabinoid system during stress', Molecular Neurobiology, vol. 39, no. 3, pp. 178-184. https://doi.org/10.1007/s12035-009-8061-4
Rossi S, De Chiara V, Musella A, Mataluni G, Sacchetti L, Bernardi G et al. Adaptations of striatal endocannabinoid system during stress. Molecular Neurobiology. 2009 Jun;39(3):178-184. https://doi.org/10.1007/s12035-009-8061-4
Rossi, Silvia ; De Chiara, Valentina ; Musella, Alessandra ; Mataluni, Giorgia ; Sacchetti, Lucia ; Bernardi, Giorgio ; Usiello, Alessandro ; Centonze, Diego. / Adaptations of striatal endocannabinoid system during stress. In: Molecular Neurobiology. 2009 ; Vol. 39, No. 3. pp. 178-184.
@article{3635b52ecd1d498d98cae477c5a8e75c,
title = "Adaptations of striatal endocannabinoid system during stress",
abstract = "The endocannabinoid system (ECS) plays a fundamental role in the regulation of synaptic transmission. Exposure to stressful events triggers synaptic adaptations in many brain areas. The activity of the ECS in stress-responsive neural circuits suggests that it may be involved in the behavioral responses and synaptic effects typical of stress. In this review, we discuss evidence demonstrating that striatal ECS is modulated by stress. Chronic stress exposure alters endocannabinoid levels, cannabinoid CB1 receptor binding and cannabinoid CB1 receptor-mediated control of inhibitory synaptic transmission in the striatum. Recent studies have shown that impairment of endocannabinoid signalling is associated with inability to adapt to chronic stress and to the development of maladaptive behaviors. The ECS represents a novel potential pharmacological target to treat stress-associated neuropsychiatric conditions.",
keywords = "Anxiety, Cocaine, Depression, FAAH, Glucocorticoids, Natural reward",
author = "Silvia Rossi and {De Chiara}, Valentina and Alessandra Musella and Giorgia Mataluni and Lucia Sacchetti and Giorgio Bernardi and Alessandro Usiello and Diego Centonze",
year = "2009",
month = "6",
doi = "10.1007/s12035-009-8061-4",
language = "English",
volume = "39",
pages = "178--184",
journal = "Molecular Neurobiology",
issn = "0893-7648",
publisher = "Humana Press Inc.",
number = "3",

}

TY - JOUR

T1 - Adaptations of striatal endocannabinoid system during stress

AU - Rossi, Silvia

AU - De Chiara, Valentina

AU - Musella, Alessandra

AU - Mataluni, Giorgia

AU - Sacchetti, Lucia

AU - Bernardi, Giorgio

AU - Usiello, Alessandro

AU - Centonze, Diego

PY - 2009/6

Y1 - 2009/6

N2 - The endocannabinoid system (ECS) plays a fundamental role in the regulation of synaptic transmission. Exposure to stressful events triggers synaptic adaptations in many brain areas. The activity of the ECS in stress-responsive neural circuits suggests that it may be involved in the behavioral responses and synaptic effects typical of stress. In this review, we discuss evidence demonstrating that striatal ECS is modulated by stress. Chronic stress exposure alters endocannabinoid levels, cannabinoid CB1 receptor binding and cannabinoid CB1 receptor-mediated control of inhibitory synaptic transmission in the striatum. Recent studies have shown that impairment of endocannabinoid signalling is associated with inability to adapt to chronic stress and to the development of maladaptive behaviors. The ECS represents a novel potential pharmacological target to treat stress-associated neuropsychiatric conditions.

AB - The endocannabinoid system (ECS) plays a fundamental role in the regulation of synaptic transmission. Exposure to stressful events triggers synaptic adaptations in many brain areas. The activity of the ECS in stress-responsive neural circuits suggests that it may be involved in the behavioral responses and synaptic effects typical of stress. In this review, we discuss evidence demonstrating that striatal ECS is modulated by stress. Chronic stress exposure alters endocannabinoid levels, cannabinoid CB1 receptor binding and cannabinoid CB1 receptor-mediated control of inhibitory synaptic transmission in the striatum. Recent studies have shown that impairment of endocannabinoid signalling is associated with inability to adapt to chronic stress and to the development of maladaptive behaviors. The ECS represents a novel potential pharmacological target to treat stress-associated neuropsychiatric conditions.

KW - Anxiety

KW - Cocaine

KW - Depression

KW - FAAH

KW - Glucocorticoids

KW - Natural reward

UR - http://www.scopus.com/inward/record.url?scp=69449106395&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69449106395&partnerID=8YFLogxK

U2 - 10.1007/s12035-009-8061-4

DO - 10.1007/s12035-009-8061-4

M3 - Article

VL - 39

SP - 178

EP - 184

JO - Molecular Neurobiology

JF - Molecular Neurobiology

SN - 0893-7648

IS - 3

ER -