Adaptive and maladaptive hypertrophic pathways: Points of convergence and divergence

Giulio Selvetella, Emilio Hirsch, Antonella Notte, Guido Tarone, Giuseppe Lembo

Research output: Contribution to journalArticlepeer-review


Myocardial hypertrophy is a response of cardiac muscle to altered conditions of haemodynamic overload caused by a large number of physiological and pathological conditions. Traditionally, it has been considered a beneficial mechanism. However, sustained hypertrophy has been associated with a significant increase in the risk of cardiovascular disease and mortality. Actually, many researchers are trying to understand whether left ventricular hypertrophy is a 'good' mechanism to stimulate or a 'bad' process to prevent. In this review we investigate the most common biochemical signaling pathways involved in the hypertrophic response to identify the precise role, either 'adaptive' or 'maladaptive', of each molecular pathway. Delinealing intracellular signaling pathways involved in the different aspects of cardiac hypertrophy will permit future improvements in the signaling that controls beneficial growth.

Original languageEnglish
Pages (from-to)373-380
Number of pages8
JournalCardiovascular Research
Issue number3
Publication statusPublished - Aug 15 2004


  • Left ventricular hypertrophy
  • Pressure overload
  • Signaling
  • Transgenic mice

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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