Adaptive optics imaging of parafoveal cones in type 1 diabetes

Marco Lombardo, Mariacristina Parravano, Giuseppe Lombardo, Monica Varano, Barbara Boccassini, Mario Stirpe, Sebastiano Serrao

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

PURPOSE:: To evaluate the parafoveal cone density in patients with Type 1 diabetes mellitus (DM1). METHODS:: Adaptive optics retinal images of the photoreceptor mosaic were acquired from 11 DM1 patients (study group) and 11 age-matched healthy subjects (control group). Cone density was analyzed, along the horizontal and vertical meridian, at 230-μm, 350-μm, and 460-μm eccentricity from the fovea. Central retinal thickness was measured using a Spectralis spectral-domain optical coherence tomography. A multiple regression model was performed to determine the relationships between the explanatory variables (age, glycohemoglobin level, presence of diabetic retinopathy, duration of diabetes, and central retinal thickness) and cone density. RESULTS:: Patients had a diagnosis of DM1 in the past 9 years to 21 years. Of these, five patients had a diagnosis of no diabetic retinopathy and six had mild nonproliferative diabetic retinopathy. On average, cone density was 10% lower in the study than in the control group at each retinal eccentricity along the horizontal and vertical meridians (analysis of variance, P <0.001). The central retinal thickness was thicker in DM1 eyes than in the control eyes (278 ± 20 μm and 260 ± 13 μm; P <0.05). The model explained 61% (P <0.01) of the variance of cone density in the population, with the variables representing an abnormal glucose metabolism, that is, a higher glycohemoglobin level, the presence of diabetic retinopathy, and a chronic diabetes, having the highest influence on cone density decline. CONCLUSION:: A subtle decrease of parafoveal cone density was found in DM1 patients in comparison with age-matched control subjects via high-resolution adaptive optics retinal imaging. The cone density decline was moderately associated with a disturbance in the glucose metabolism.

Original languageEnglish
Pages (from-to)546-557
Number of pages12
JournalRetina
Volume34
Issue number3
DOIs
Publication statusPublished - Mar 2014

Fingerprint

Type 1 Diabetes Mellitus
Diabetic Retinopathy
Meridians
Retinal Cone Photoreceptor Cells
Glucose
Control Groups
Vertebrate Photoreceptor Cells
Optical Coherence Tomography
Population Density
Analysis of Variance
Healthy Volunteers
Age Groups

Keywords

  • adaptive optics retinal imaging
  • central retinal thickness
  • cone density
  • diabetic retinopathy

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Adaptive optics imaging of parafoveal cones in type 1 diabetes. / Lombardo, Marco; Parravano, Mariacristina; Lombardo, Giuseppe; Varano, Monica; Boccassini, Barbara; Stirpe, Mario; Serrao, Sebastiano.

In: Retina, Vol. 34, No. 3, 03.2014, p. 546-557.

Research output: Contribution to journalArticle

Lombardo, Marco ; Parravano, Mariacristina ; Lombardo, Giuseppe ; Varano, Monica ; Boccassini, Barbara ; Stirpe, Mario ; Serrao, Sebastiano. / Adaptive optics imaging of parafoveal cones in type 1 diabetes. In: Retina. 2014 ; Vol. 34, No. 3. pp. 546-557.
@article{7b44c448bc3344cb8cdef1f35400d021,
title = "Adaptive optics imaging of parafoveal cones in type 1 diabetes",
abstract = "PURPOSE:: To evaluate the parafoveal cone density in patients with Type 1 diabetes mellitus (DM1). METHODS:: Adaptive optics retinal images of the photoreceptor mosaic were acquired from 11 DM1 patients (study group) and 11 age-matched healthy subjects (control group). Cone density was analyzed, along the horizontal and vertical meridian, at 230-μm, 350-μm, and 460-μm eccentricity from the fovea. Central retinal thickness was measured using a Spectralis spectral-domain optical coherence tomography. A multiple regression model was performed to determine the relationships between the explanatory variables (age, glycohemoglobin level, presence of diabetic retinopathy, duration of diabetes, and central retinal thickness) and cone density. RESULTS:: Patients had a diagnosis of DM1 in the past 9 years to 21 years. Of these, five patients had a diagnosis of no diabetic retinopathy and six had mild nonproliferative diabetic retinopathy. On average, cone density was 10{\%} lower in the study than in the control group at each retinal eccentricity along the horizontal and vertical meridians (analysis of variance, P <0.001). The central retinal thickness was thicker in DM1 eyes than in the control eyes (278 ± 20 μm and 260 ± 13 μm; P <0.05). The model explained 61{\%} (P <0.01) of the variance of cone density in the population, with the variables representing an abnormal glucose metabolism, that is, a higher glycohemoglobin level, the presence of diabetic retinopathy, and a chronic diabetes, having the highest influence on cone density decline. CONCLUSION:: A subtle decrease of parafoveal cone density was found in DM1 patients in comparison with age-matched control subjects via high-resolution adaptive optics retinal imaging. The cone density decline was moderately associated with a disturbance in the glucose metabolism.",
keywords = "adaptive optics retinal imaging, central retinal thickness, cone density, diabetic retinopathy",
author = "Marco Lombardo and Mariacristina Parravano and Giuseppe Lombardo and Monica Varano and Barbara Boccassini and Mario Stirpe and Sebastiano Serrao",
year = "2014",
month = "3",
doi = "10.1097/IAE.0b013e3182a10850",
language = "English",
volume = "34",
pages = "546--557",
journal = "Retina",
issn = "0275-004X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Adaptive optics imaging of parafoveal cones in type 1 diabetes

AU - Lombardo, Marco

AU - Parravano, Mariacristina

AU - Lombardo, Giuseppe

AU - Varano, Monica

AU - Boccassini, Barbara

AU - Stirpe, Mario

AU - Serrao, Sebastiano

PY - 2014/3

Y1 - 2014/3

N2 - PURPOSE:: To evaluate the parafoveal cone density in patients with Type 1 diabetes mellitus (DM1). METHODS:: Adaptive optics retinal images of the photoreceptor mosaic were acquired from 11 DM1 patients (study group) and 11 age-matched healthy subjects (control group). Cone density was analyzed, along the horizontal and vertical meridian, at 230-μm, 350-μm, and 460-μm eccentricity from the fovea. Central retinal thickness was measured using a Spectralis spectral-domain optical coherence tomography. A multiple regression model was performed to determine the relationships between the explanatory variables (age, glycohemoglobin level, presence of diabetic retinopathy, duration of diabetes, and central retinal thickness) and cone density. RESULTS:: Patients had a diagnosis of DM1 in the past 9 years to 21 years. Of these, five patients had a diagnosis of no diabetic retinopathy and six had mild nonproliferative diabetic retinopathy. On average, cone density was 10% lower in the study than in the control group at each retinal eccentricity along the horizontal and vertical meridians (analysis of variance, P <0.001). The central retinal thickness was thicker in DM1 eyes than in the control eyes (278 ± 20 μm and 260 ± 13 μm; P <0.05). The model explained 61% (P <0.01) of the variance of cone density in the population, with the variables representing an abnormal glucose metabolism, that is, a higher glycohemoglobin level, the presence of diabetic retinopathy, and a chronic diabetes, having the highest influence on cone density decline. CONCLUSION:: A subtle decrease of parafoveal cone density was found in DM1 patients in comparison with age-matched control subjects via high-resolution adaptive optics retinal imaging. The cone density decline was moderately associated with a disturbance in the glucose metabolism.

AB - PURPOSE:: To evaluate the parafoveal cone density in patients with Type 1 diabetes mellitus (DM1). METHODS:: Adaptive optics retinal images of the photoreceptor mosaic were acquired from 11 DM1 patients (study group) and 11 age-matched healthy subjects (control group). Cone density was analyzed, along the horizontal and vertical meridian, at 230-μm, 350-μm, and 460-μm eccentricity from the fovea. Central retinal thickness was measured using a Spectralis spectral-domain optical coherence tomography. A multiple regression model was performed to determine the relationships between the explanatory variables (age, glycohemoglobin level, presence of diabetic retinopathy, duration of diabetes, and central retinal thickness) and cone density. RESULTS:: Patients had a diagnosis of DM1 in the past 9 years to 21 years. Of these, five patients had a diagnosis of no diabetic retinopathy and six had mild nonproliferative diabetic retinopathy. On average, cone density was 10% lower in the study than in the control group at each retinal eccentricity along the horizontal and vertical meridians (analysis of variance, P <0.001). The central retinal thickness was thicker in DM1 eyes than in the control eyes (278 ± 20 μm and 260 ± 13 μm; P <0.05). The model explained 61% (P <0.01) of the variance of cone density in the population, with the variables representing an abnormal glucose metabolism, that is, a higher glycohemoglobin level, the presence of diabetic retinopathy, and a chronic diabetes, having the highest influence on cone density decline. CONCLUSION:: A subtle decrease of parafoveal cone density was found in DM1 patients in comparison with age-matched control subjects via high-resolution adaptive optics retinal imaging. The cone density decline was moderately associated with a disturbance in the glucose metabolism.

KW - adaptive optics retinal imaging

KW - central retinal thickness

KW - cone density

KW - diabetic retinopathy

UR - http://www.scopus.com/inward/record.url?scp=84894463966&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84894463966&partnerID=8YFLogxK

U2 - 10.1097/IAE.0b013e3182a10850

DO - 10.1097/IAE.0b013e3182a10850

M3 - Article

VL - 34

SP - 546

EP - 557

JO - Retina

JF - Retina

SN - 0275-004X

IS - 3

ER -