Adaptive optics retinal imaging-clinical opportunities and challenges

Joseph Carroll, David B. Kay, Drew Scoles, Alfredo Dubra, Marco Lombardo

Research output: Contribution to journalArticle

Abstract

The array of therapeutic options available to clinicians for treating retinal disease is expanding. With these advances comes the need for better understanding of the etiology of these diseases on a cellular level as well as improved non-invasive tools for identifying the best candidates for given therapies and monitoring the efficacy of those therapies. While spectral domain optical coherence tomography offers a widely available tool for clinicians to assay the living retina, it suffers from poor lateral resolution due to the eye's monochromatic aberrations. Ophthalmic adaptive optics (AO) is a technique to compensate for the eye's aberrations and provide nearly diffraction-limited resolution. The result is the ability to visualize the living retina with cellular resolution. While AO is unquestionably a powerful research tool, many clinicians remain undecided on the clinical potential of AO imaging-putting many at a crossroads with respect to adoption of this technology. This review will briefly summarize the current state of AO retinal imaging, discuss current as well as future clinical applications of AO retinal imaging, and finally provide some discussion of research needs to facilitate more widespread clinical use.

Original languageEnglish
Pages (from-to)709-721
Number of pages13
JournalCurrent Eye Research
Volume38
Issue number7
DOIs
Publication statusPublished - 2013

Keywords

  • Adaptive optics
  • Photoreceptor
  • Retinal degeneration
  • Retinal imaging

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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    Carroll, J., Kay, D. B., Scoles, D., Dubra, A., & Lombardo, M. (2013). Adaptive optics retinal imaging-clinical opportunities and challenges. Current Eye Research, 38(7), 709-721. https://doi.org/10.3109/02713683.2013.784792