Adaptive servo ventilation reduces central sleep apnea in chronic heart failure patients: Beneficial effects on autonomic modulation of heart rate

Emilia D'Elia, Emilio Vanoli, Maria T. La Rovere, Francesco Fanfulla, Alessandra Maggioni, Valentina Casali, Simona Damiano, Giuseppe Specchia, Andrea Mortara

Research output: Contribution to journalArticlepeer-review

Abstract

AIM: Adaptive servo ventilation (ASV) is a method of ventilator support aimed to treat central sleep apnea (CSA). We investigated the effects of an acute use of ASV in chronic heart failure (CHF) patients with CSA and the potential influence on sympathetic nerve activity. METHODS: Patients were studied with ambulatory cardio-respiratory 24 Holter (Somtè) recording of air flow, ECG and oxygen saturation. Comparison before and after ASV treatment was made for apnea index (AI), apnea-hypopnea index (AHI), pulse oxygen saturation, desaturation related to apnea, heart rate (HR) and heart rate variability (HRV). RESULTS: Seventeen patients were enrolled. At baseline, apnea index and apnea-hypopnea index were, respectively, 16.92±7.8 and 41.37±17.5. During ASV, they significantly decreased to 0.06±0.0 (P

Original languageEnglish
Pages (from-to)296-300
Number of pages5
JournalJournal of Cardiovascular Medicine
Volume14
Issue number4
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Central sleep apnea
  • Chronic heart failure
  • Heart rate
  • Heart rate variability
  • Oxygen saturation
  • Sympathetic nervous system

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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