Adaptive support ventilation versus conventional ventilation for total ventilatory support in acute respiratory failure

Giorgio A. Iotti, Andrea Polito, Mirko Belliato, Daniela Pasero, Gaetan Beduneau, Marc Wysocki, Josef X. Brunner, Antonio Braschi, Laurent Brochard, Jordi Mancebo, V. Marco Ranieri, Jean Christophe M Richard, S. Slutsky Arthur

Research output: Contribution to journalArticle

Abstract

Objective: To compare the short-term effects of adaptive support ventilation (ASV), an advanced closed-loop mode, with conventional volume or pressurecontrol ventilation in patients passively ventilated for acute respiratory failure. Design: Prospective crossover interventional multicenter trial. Setting: Six European academic intensive care units. Patients: Eighty-eight patients in three groups: patients with no obvious lung disease (n = 22), restrictive lung disease (n = 36) or obstructive lung disease (n = 30). Interventions: After measurements on conventional ventilation (CV) as set by the patients' clinicians, each patient was switched to ASV set to obtain the same minute ventilation as during CV (isoMV condition). If this resulted in a change in PaCO2, the minute ventilation setting of ASV was readjusted to achieve the same PaCO2 as in CV (isoCO2 condition). Measurements and results: Compared with CV, PaCO2 during ASV in isoMV condition and minute ventilation during ASV in isoCO2 condition were slightly lower, with lower inspiratory work/minute performed by the ventilator (p

Original languageEnglish
Pages (from-to)1371-1379
Number of pages9
JournalIntensive Care Medicine
Volume36
Issue number8
DOIs
Publication statusPublished - Aug 2010

Keywords

  • Breathing pattern
  • Carbon dioxide elimination
  • Closed-loop ventilation
  • Mechanical ventilation
  • Respiratory mechanics
  • Work of breathing

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine
  • Medicine(all)

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    Iotti, G. A., Polito, A., Belliato, M., Pasero, D., Beduneau, G., Wysocki, M., Brunner, J. X., Braschi, A., Brochard, L., Mancebo, J., Ranieri, V. M., Richard, J. C. M., & Arthur, S. S. (2010). Adaptive support ventilation versus conventional ventilation for total ventilatory support in acute respiratory failure. Intensive Care Medicine, 36(8), 1371-1379. https://doi.org/10.1007/s00134-010-1917-2