Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images

Francesca Gallivanone; Federico Fazio; Luca Presotto; Maria C. Gilardi; Carla Canevari; Isabella Castiglioni

doi:10.1109/NSSMIC.2013.6829383

Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images

Francesca Gallivanone, Federico Fazio, Luca Presotto, Maria C. Gilardi, Carla Canevari, Isabella Castiglioni

IRCCS Ospedale San Raffaele

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Most advanced radiotherapy planning can be optimized by incorporating the metabolic image of the tumour to be irradiated (Metabolic Target Volume). MTV can be properly obtained by in vivo molecular imaging studies as the volume of metabolically active tumour component. Positron EmissionTomography (PET) can provide MTV by in vivo measuring the glucose metabolism of a tumour. Aim of this work was to develop an innovative PET image segmentation method, based on an adaptive threshold of the image signal-to-noise ratio, for the estimation of the MTV. The proposed method was tested on a set of anthropomorphic phantoms proving its feasibility, operator-independency and accuracy in a clinical setting.

Original language	English
Title of host publication	IEEE Nuclear Science Symposium Conference Record
Publisher	Institute of Electrical and Electronics Engineers Inc.
ISBN (Print)	9781479905348
DOIs	https://doi.org/10.1109/NSSMIC.2013.6829383
Publication status	Published - 2013
Event	2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013 - Seoul, Korea, Republic of Duration: Oct 27 2013 → Nov 2 2013

Other

Other	2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013
Country	Korea, Republic of
City	Seoul
Period	10/27/13 → 11/2/13

ASJC Scopus subject areas

Radiation
Nuclear and High Energy Physics
Radiology Nuclear Medicine and imaging

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Gallivanone, F., Fazio, F., Presotto, L., Gilardi, M. C., Canevari, C., & Castiglioni, I. (2013). Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images. In IEEE Nuclear Science Symposium Conference Record [6829383] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NSSMIC.2013.6829383

Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images. / Gallivanone, Francesca; Fazio, Federico; Presotto, Luca; Gilardi, Maria C.; Canevari, Carla; Castiglioni, Isabella.

IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013. 6829383.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Gallivanone, F, Fazio, F, Presotto, L, Gilardi, MC, Canevari, C & Castiglioni, I 2013, Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images. in IEEE Nuclear Science Symposium Conference Record., 6829383, Institute of Electrical and Electronics Engineers Inc., 2013 60th IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2013, Seoul, Korea, Republic of, 10/27/13. https://doi.org/10.1109/NSSMIC.2013.6829383

Gallivanone F, Fazio F, Presotto L, Gilardi MC, Canevari C, Castiglioni I. Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images. In IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc. 2013. 6829383 https://doi.org/10.1109/NSSMIC.2013.6829383

Gallivanone, Francesca ; Fazio, Federico ; Presotto, Luca ; Gilardi, Maria C. ; Canevari, Carla ; Castiglioni, Isabella. / Adaptive threshold method based on PET measured lesion-to-background ratio for the estimation of Metabolic Target Volume from 18F-FDG PET images. IEEE Nuclear Science Symposium Conference Record. Institute of Electrical and Electronics Engineers Inc., 2013.

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abstract = "Most advanced radiotherapy planning can be optimized by incorporating the metabolic image of the tumour to be irradiated (Metabolic Target Volume). MTV can be properly obtained by in vivo molecular imaging studies as the volume of metabolically active tumour component. Positron EmissionTomography (PET) can provide MTV by in vivo measuring the glucose metabolism of a tumour. Aim of this work was to develop an innovative PET image segmentation method, based on an adaptive threshold of the image signal-to-noise ratio, for the estimation of the MTV. The proposed method was tested on a set of anthropomorphic phantoms proving its feasibility, operator-independency and accuracy in a clinical setting.",

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