ADAR2 editing enzyme is a novel human immunodeficiency virus-1 proviral factor

Margherita Doria, Sara Tomaselli, Francesca Neri, Silvia Anna Ciafrè, Maria Giulia Farace, Alessandro Michienzi, Angela Gallo

Research output: Contribution to journalArticlepeer-review

Abstract

The adenosine deaminases acting on RNA (ADAR) enzymes catalyse conversion of adenosine to inosine in dsRNA. A positive effect of ADAR1 on human immunodeficiency virus type 1 (HIV-1) replication has recently been reported. Here, we show that another ADAR enzyme, ADAR2, positively affects the replication process of HIV-1. We found that, analogously to ADAR1, ADAR2 enhances the release of progeny virions by an editing-dependent mechanism. However, differently from the ADAR1 enzyme, ADAR2 does not increase the infectious potential of the virus. Importantly, downregulation of ADAR2 in Jurkat cells significantly impairs viral replication. Therefore, ADAR2 shares some but not all proviral functions of ADAR1. These results suggest a novel role of ADAR2 as a viral regulator.

Original languageEnglish
Pages (from-to)1228-1232
Number of pages5
JournalJournal of General Virology
Volume92
Issue number5
DOIs
Publication statusPublished - May 2011

ASJC Scopus subject areas

  • Virology

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