Abstract
All viruses that have dsRNA structures at any stages of their life cycle may potentially undergo RNA editing events mediated by ADAR enzymes. Indeed, an increasing number of studies that describe A-to-I sequence changes in viral genomes and/or transcripts, consistent with ADAR deaminase activity, has been reported so far. These modifications can appear as either hyperediting or specific RNA editing events in viral dsRNAs. It is now well established that ADAR enzymes can affect viral life cycles in an editing-dependent and -independent manner, with ADARs acting as pro- or antiviral factors. Despite the discovery of editing events in viral RNAs dates back to thirty years ago, the biological consequences of A-to-I changes during viral infection is still far to be completely elucidated. In this review, past and recent studies on the importance of ADAR enzymes on several viruses will be examined.
| Original language | English |
|---|---|
| Pages (from-to) | 37-52 |
| Number of pages | 16 |
| Journal | Current Issues in Molecular Biology |
| Volume | 17 |
| Issue number | 1 |
| Publication status | Published - 2015 |
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ASJC Scopus subject areas
- Molecular Biology
- Microbiology
- Microbiology (medical)
Cite this
Adars and the balance game between virus infection and innate immune cell response. / Tomaselli, Sara; Galeano, Federica; Locatelli, Franco; Gallo, Angela.
In: Current Issues in Molecular Biology, Vol. 17, No. 1, 2015, p. 37-52.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Adars and the balance game between virus infection and innate immune cell response
AU - Tomaselli, Sara
AU - Galeano, Federica
AU - Locatelli, Franco
AU - Gallo, Angela
PY - 2015
Y1 - 2015
N2 - All viruses that have dsRNA structures at any stages of their life cycle may potentially undergo RNA editing events mediated by ADAR enzymes. Indeed, an increasing number of studies that describe A-to-I sequence changes in viral genomes and/or transcripts, consistent with ADAR deaminase activity, has been reported so far. These modifications can appear as either hyperediting or specific RNA editing events in viral dsRNAs. It is now well established that ADAR enzymes can affect viral life cycles in an editing-dependent and -independent manner, with ADARs acting as pro- or antiviral factors. Despite the discovery of editing events in viral RNAs dates back to thirty years ago, the biological consequences of A-to-I changes during viral infection is still far to be completely elucidated. In this review, past and recent studies on the importance of ADAR enzymes on several viruses will be examined.
AB - All viruses that have dsRNA structures at any stages of their life cycle may potentially undergo RNA editing events mediated by ADAR enzymes. Indeed, an increasing number of studies that describe A-to-I sequence changes in viral genomes and/or transcripts, consistent with ADAR deaminase activity, has been reported so far. These modifications can appear as either hyperediting or specific RNA editing events in viral dsRNAs. It is now well established that ADAR enzymes can affect viral life cycles in an editing-dependent and -independent manner, with ADARs acting as pro- or antiviral factors. Despite the discovery of editing events in viral RNAs dates back to thirty years ago, the biological consequences of A-to-I changes during viral infection is still far to be completely elucidated. In this review, past and recent studies on the importance of ADAR enzymes on several viruses will be examined.
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M3 - Article
C2 - 25502818
AN - SCOPUS:84922418223
VL - 17
SP - 37
EP - 52
JO - Current Issues in Molecular Biology
JF - Current Issues in Molecular Biology
SN - 1467-3037
IS - 1
ER -