ADAS-CoG and mental deterioration battery: Different instruments for different aspects of cognitive decline in Alzheimer's disease

Laura Serra, Roberta Perri, Giovanni Augusto Carlesimo, Lucia Fadda, Sebastiano Lorusso, Alessandro Padovani, Carla Pettenati, Maia Vegliante, Carlo Caltagirone

Research output: Contribution to journalArticle

Abstract

Objective: Aim of this study was to compare ADAS-Cog and MDB, instruments usually used in cognitive assessment of AD patients, relative to: 1) diagnostic sensitivity for dementia of AD; 2) ability to rate the progression of cognitive decline and ability to detect the qualitative characteristics of cognitive decline. Material and methods: A sample of 54 AD patients was submitted to a cognitive assessment with both battery at time of study entry (T 0) and after 12 months (T 12). Results: This study showed: 1) a better diagnostic sensitivity of MDB respect to ADAS-Cog in diagnosing patients affected by mild to moderate levels of AD; 2) a better sensitivity of ADAS-Cog to follow the cognitive decline over a twelve-months period Conclusion: These results supports the use of the MDB in the screening phase of AD patients and of ADAS-Cog to follow the progression of cognitive decline over time.

Original languageEnglish
Pages (from-to)184-192
Number of pages9
JournalNeuroscience Research Communications
Volume35
Issue number3
DOIs
Publication statusPublished - Nov 2004

Keywords

  • ADAS-Cog
  • Alzheimer's disease
  • Cognitive decline
  • Mental Deterioration Battery

ASJC Scopus subject areas

  • Neuroscience(all)

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