Add-on high frequency deep transcranial magnetic stimulation (dTMS) to bilateral prefrontal cortex reduces cocaine craving in patients with cocaine use disorder

Chiara Rapinesi, Antonio Del Casale, Simone Di Pietro, Vittoria Rachele Ferri, Daria Piacentino, Gabriele Sani, Ruggero Nessim Raccah, Abraham Zangen, Stefano Ferracuti, Alessandro Emiliano Vento, Gloria Angeletti, Roberto Brugnoli, Georgios D. Kotzalidis, Paolo Girardi

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction Cocaine dependence is a substantial public health problem. The aim of this study is to evaluate the effect of high frequency deep transcranial magnetic stimulation (dTMS) on craving in patients with cocaine use disorder (CUD). Methods Seven men (mean age, 48.71 years; standard deviation [SD], 9.45; range 32–60 years) with CUD and no concurrent axis 1 or 2 disorder save nicotine abuse, underwent three sessions of alternate day 20 Hz dTMS in 20 trains delivered to the dorsolateral prefrontal cortex (DLPFC) preferentially to the left hemisphere, for 12 sessions spread over one month, added to unchanged prior drug treatment. We used a visual analogue scale (VAS) to measure cocaine craving the week before, each week during, and one month after dTMS treatment. Results DLPFC stimulation significantly reduced craving over time: within-subjects main effect of time of treatment (ANOVA, F[3,18] = 46.154; p 2 = 0.88). The reduction of craving from baseline was significant at two weeks (p 

Original languageEnglish
Pages (from-to)43-47
Number of pages5
JournalNeuroscience Letters
Volume629
DOIs
Publication statusPublished - Aug 26 2016
Externally publishedYes

Keywords

  • Cocaine use disorder
  • Craving
  • Deep Transcranial Magnetic Stimulation (dTMS)
  • Dorsolateral Prefrontal Cortex (DLPFC)

ASJC Scopus subject areas

  • Neuroscience(all)

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