Abstract
Patients experiencing dyspnoea can request an additional dose of salmeterol during the dose interval for the control of their symptoms, although under treatment with salmeterol. In this study we have explored the effects on respiratory function of an additive dose of salmeterol Diskus® in 15 chronic obstructive pulmonary disease (COPD) patients in regular treatment with a conventional dose of 50 μg salmeterol. On two different days, patients inhaled 50 μg Diskus®. After 240 min, they inhaled additional 50 μg salmeterol Diskus® (salmeterol arm) or placebo Diskus® (placebo arm). Lung function was controlled before first drug administration and 0.5, 1, 2, 3, 4, 4.5, 6, 8, 10, and 12 h thereafter. The mean (95% CI) peak increase in FEV1 from baseline was reached after 4 h in the salmeterol arm (0.174 L; 0.144-0204) and after 5 h (0.141 L; 0.115-0.168) in the placebo arm; after 12 h, the mean (95% CI) increase in FEV1 from basal values was still 0.149 L (0.119-0.179) in salmeterol arm, but only 0.041 L (0.017-0.064) in placebo arm. The mean (95% CI) FEV1 AUC0-12h for all patients were 2.01 (1.72-2.30) L when salmeterol was added and 1.30 (1.03-1.58) L when placebo was inhaled. The difference (mean; 95% CI) between the FEV1 AUC0-12h of the two arms (0.71 L; 0.47-0.95) was statistically significant (P <0.0001), although the difference (mean; 95% CI) between the FEV1 AUC0-4h of the two treatments (0.08 L; -0.02-0.18) was not statistically significant (P=0.126). The addition of an extra dose of salmeterol did not significantly increase the heart rate or decrease the SpO2. This study suggests that the addition of an extra dose of salmeterol does not give room for further increase in peak FEV1, but the effect of adding salmeterol to salmeterol is largely additive when considering the duration of action and safe.
| Original language | English |
|---|---|
| Pages (from-to) | 439-443 |
| Number of pages | 5 |
| Journal | Respiratory Medicine |
| Volume | 96 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 1 2002 |
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Keywords
- COPD
- Extra dose
- Salmeterol
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
Cite this
Addition of an extra dose of salmeterol Diskus® to conventional dose of salmeterol Diskus® in patients with COPD. / Cazzola, M.; Santus, P.; Castagna, F.; Di Marco, F.; Terzano, C.; Matera, M. G.; Centanni, S.
In: Respiratory Medicine, Vol. 96, No. 6, 01.06.2002, p. 439-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Addition of an extra dose of salmeterol Diskus® to conventional dose of salmeterol Diskus® in patients with COPD
AU - Cazzola, M.
AU - Santus, P.
AU - Castagna, F.
AU - Di Marco, F.
AU - Terzano, C.
AU - Matera, M. G.
AU - Centanni, S.
PY - 2002/6/1
Y1 - 2002/6/1
N2 - Patients experiencing dyspnoea can request an additional dose of salmeterol during the dose interval for the control of their symptoms, although under treatment with salmeterol. In this study we have explored the effects on respiratory function of an additive dose of salmeterol Diskus® in 15 chronic obstructive pulmonary disease (COPD) patients in regular treatment with a conventional dose of 50 μg salmeterol. On two different days, patients inhaled 50 μg Diskus®. After 240 min, they inhaled additional 50 μg salmeterol Diskus® (salmeterol arm) or placebo Diskus® (placebo arm). Lung function was controlled before first drug administration and 0.5, 1, 2, 3, 4, 4.5, 6, 8, 10, and 12 h thereafter. The mean (95% CI) peak increase in FEV1 from baseline was reached after 4 h in the salmeterol arm (0.174 L; 0.144-0204) and after 5 h (0.141 L; 0.115-0.168) in the placebo arm; after 12 h, the mean (95% CI) increase in FEV1 from basal values was still 0.149 L (0.119-0.179) in salmeterol arm, but only 0.041 L (0.017-0.064) in placebo arm. The mean (95% CI) FEV1 AUC0-12h for all patients were 2.01 (1.72-2.30) L when salmeterol was added and 1.30 (1.03-1.58) L when placebo was inhaled. The difference (mean; 95% CI) between the FEV1 AUC0-12h of the two arms (0.71 L; 0.47-0.95) was statistically significant (P <0.0001), although the difference (mean; 95% CI) between the FEV1 AUC0-4h of the two treatments (0.08 L; -0.02-0.18) was not statistically significant (P=0.126). The addition of an extra dose of salmeterol did not significantly increase the heart rate or decrease the SpO2. This study suggests that the addition of an extra dose of salmeterol does not give room for further increase in peak FEV1, but the effect of adding salmeterol to salmeterol is largely additive when considering the duration of action and safe.
AB - Patients experiencing dyspnoea can request an additional dose of salmeterol during the dose interval for the control of their symptoms, although under treatment with salmeterol. In this study we have explored the effects on respiratory function of an additive dose of salmeterol Diskus® in 15 chronic obstructive pulmonary disease (COPD) patients in regular treatment with a conventional dose of 50 μg salmeterol. On two different days, patients inhaled 50 μg Diskus®. After 240 min, they inhaled additional 50 μg salmeterol Diskus® (salmeterol arm) or placebo Diskus® (placebo arm). Lung function was controlled before first drug administration and 0.5, 1, 2, 3, 4, 4.5, 6, 8, 10, and 12 h thereafter. The mean (95% CI) peak increase in FEV1 from baseline was reached after 4 h in the salmeterol arm (0.174 L; 0.144-0204) and after 5 h (0.141 L; 0.115-0.168) in the placebo arm; after 12 h, the mean (95% CI) increase in FEV1 from basal values was still 0.149 L (0.119-0.179) in salmeterol arm, but only 0.041 L (0.017-0.064) in placebo arm. The mean (95% CI) FEV1 AUC0-12h for all patients were 2.01 (1.72-2.30) L when salmeterol was added and 1.30 (1.03-1.58) L when placebo was inhaled. The difference (mean; 95% CI) between the FEV1 AUC0-12h of the two arms (0.71 L; 0.47-0.95) was statistically significant (P <0.0001), although the difference (mean; 95% CI) between the FEV1 AUC0-4h of the two treatments (0.08 L; -0.02-0.18) was not statistically significant (P=0.126). The addition of an extra dose of salmeterol did not significantly increase the heart rate or decrease the SpO2. This study suggests that the addition of an extra dose of salmeterol does not give room for further increase in peak FEV1, but the effect of adding salmeterol to salmeterol is largely additive when considering the duration of action and safe.
KW - COPD
KW - Extra dose
KW - Salmeterol
UR - http://www.scopus.com/inward/record.url?scp=0036591413&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036591413&partnerID=8YFLogxK
U2 - 10.1053/rmed.2001.1279
DO - 10.1053/rmed.2001.1279
M3 - Article
C2 - 12117044
AN - SCOPUS:0036591413
VL - 96
SP - 439
EP - 443
JO - Respiratory Medicine
JF - Respiratory Medicine
SN - 0954-6111
IS - 6
ER -