Addition of atropine to submaximal exercise stress testing in patients evaluated for suspected ischaemia with SPECT imaging: A randomized, placebo-controlled trial

Fiore Manganelli, Marco Spadafora, Paola Varrella, Giuseppina Peluso, Rosario Sauro, Emilio Di Lorenzo, Giuseppe Rosato, Stefania Daniele, Alberto Cuocolo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: To evaluate the effects of the addition of atropine to exercise testing in patients who failed to achieve their target heart rate (HR) during stress myocardial perfusion imaging with single-photon emission computed tomography (SPECT). Methods: The study was a prospective, randomized, placebo-controlled design. Patients with suspected or known coronary artery disease who failed to achieve a target HR (≥85% of maximal predicted HR) during exercise SPECT imaging were randomized to receive intravenous atropine (n=100) or placebo (n=101). Results: The two groups of patients did not differ with respect to demographic or clinical characteristics. A higher proportion of patients in the atropine group achieved the target HR compared to the placebo group (60% versus 3%, p

Original languageEnglish
Pages (from-to)245-251
Number of pages7
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Volume38
Issue number2
DOIs
Publication statusPublished - Feb 2011

Keywords

  • Atropine
  • Exercise stress testing
  • Myocardial perfusion imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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