Addition of the multidimensional prognostic index to the estimated glomerular filtration rate improves prediction of long-term all-cause mortality in older patients with chronic kidney disease

Alberto Pilotto, Daniele Sancarlo, Filippo Aucella, Andrea Fontana, Filomena Addante, Massimiliano Copetti, Francesco Panza, Giovanni F M Strippoli, Luigi Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

Current prognostic scores of chronic kidney disease (CKD) are not accurate in older patients. The aim of this study was to evaluate the prognostic accuracy of the Multidimensional Prognostic Index (MPI) in comparison with and in addition to the estimated glomerular filtration rate (eGFR) to predict long-term all-cause mortality in hospitalized older patients with CKD. In a prospective cohort study with a mean follow-up of 2 years, we calculated eGFR according to the Modification of Diet in Renal Disease study and collected information on functional, cognitive, nutritional, co-morbidities, drug use, and co-habitation status to calculate the MPI on 1,198 patients aged ≥65 years with a diagnosis of CKD from an hospital-based sample. The all-cause mortality incidence rate for 100 person-years was 18.3 (men 22.7 vs. women 15.3, p

Original languageEnglish
Pages (from-to)82-88
Number of pages7
JournalRejuvenation Research
Volume15
Issue number1
DOIs
Publication statusPublished - Feb 1 2012

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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