Additional resources and the default mode network: Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis

Johanna Heimrath, Martin Gorges, Jan Kassubek, Hans Peter Müller, Niels Birbaumer, Albert C. Ludolph, Dorothée Lulé

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In amyotrophic lateral sclerosis (ALS), cognition is affected. Cortical atrophy in frontal and temporal areas has been associated with the cognitive profile of patients. Additionally, reduced metabolic turnover and regional cerebral blood flow in frontal areas indicative of reduced neural activity have been reported for ALS. We hypothesize that functional connectivity in non-task associated functional default mode network (DMN) is associated with cognitive profile and white matter integrity. This study focused on specific cognitive tasks known to be impaired in ALS such as verbal fluency and attention, and the relationship with functional connectivity in the DMN and white matter integrity. Nine patients and 11 controls were measured with an extensive neuropsychological battery. Resting-state functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) data were acquired. Results showed that ALS patients performed significantly worse in attention and verbal fluency task. Patients showed increased functional connectivity in parahippocampal and parietal areas of the non-task associated DMN compared to controls. The more pronounced the cognitive deficits, the stronger the increase in functional connectivity in those areas. White matter integrity was reduced in frontal areas in the patients. In conclusion, increased connectivity in the DMN in parahippocampal and parietal areas might represent recruitment of accessory brain regions to compensate for dysfunctional frontal networks.

Original languageEnglish
Pages (from-to)537-545
Number of pages9
JournalAmyotrophic Lateral Sclerosis and Frontotemporal Degeneration
Volume15
Issue number7-8
DOIs
Publication statusPublished - Dec 1 2014

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Amyotrophic Lateral Sclerosis
Cerebrovascular Circulation
Diffusion Tensor Imaging
Regional Blood Flow
Cognition
Atrophy
Magnetic Resonance Imaging
White Matter
Brain

Keywords

  • Amyotrophic lateral sclerosis (ALS)
  • Cognition
  • Cortical plasticity
  • Default mode network
  • fMRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Additional resources and the default mode network : Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis. / Heimrath, Johanna; Gorges, Martin; Kassubek, Jan; Müller, Hans Peter; Birbaumer, Niels; Ludolph, Albert C.; Lulé, Dorothée.

In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, Vol. 15, No. 7-8, 01.12.2014, p. 537-545.

Research output: Contribution to journalArticle

Heimrath, Johanna ; Gorges, Martin ; Kassubek, Jan ; Müller, Hans Peter ; Birbaumer, Niels ; Ludolph, Albert C. ; Lulé, Dorothée. / Additional resources and the default mode network : Evidence of increased connectivity and decreased white matter integrity in amyotrophic lateral sclerosis. In: Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 2014 ; Vol. 15, No. 7-8. pp. 537-545.
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