Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT

Alberto Bestetti, Besart Cuko, Adriano Decarli, Alessio Galli, Federico Lombardi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of 99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1% ± 10.3% vs 50.3% ± 10.7%; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.

Original languageEnglish
Pages (from-to)833-840
Number of pages8
JournalJournal of Nuclear Cardiology
Volume26
Issue number3
DOIs
Publication statusPublished - 2019

Fingerprint

Myocardial Stunning
Single-Photon Emission-Computed Tomography
Perfusion
Ischemia
Angiography
Exercise Test
Heart Ventricles
Myocardial Ischemia
Coronary Artery Disease
Multivariate Analysis
Regression Analysis

Keywords

  • cardiac single-photon emission computed tomography
  • Coronary artery disease
  • ischemic heart disease
  • myocardial stunning

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT. / Bestetti, Alberto; Cuko, Besart; Decarli, Adriano; Galli, Alessio; Lombardi, Federico.

In: Journal of Nuclear Cardiology, Vol. 26, No. 3, 2019, p. 833-840.

Research output: Contribution to journalArticle

Bestetti, Alberto ; Cuko, Besart ; Decarli, Adriano ; Galli, Alessio ; Lombardi, Federico. / Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT. In: Journal of Nuclear Cardiology. 2019 ; Vol. 26, No. 3. pp. 833-840.
@article{5487edf0a4ab4160a208963785a38edf,
title = "Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT",
abstract = "Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of 99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1{\%} ± 10.3{\%} vs 50.3{\%} ± 10.7{\%}; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.",
keywords = "cardiac single-photon emission computed tomography, Coronary artery disease, ischemic heart disease, myocardial stunning",
author = "Alberto Bestetti and Besart Cuko and Adriano Decarli and Alessio Galli and Federico Lombardi",
year = "2019",
doi = "10.1007/s12350-017-1115-5",
language = "English",
volume = "26",
pages = "833--840",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Additional value of systolic wall thickening in myocardial stunning evaluated by stress-rest gated perfusion SPECT

AU - Bestetti, Alberto

AU - Cuko, Besart

AU - Decarli, Adriano

AU - Galli, Alessio

AU - Lombardi, Federico

PY - 2019

Y1 - 2019

N2 - Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of 99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1% ± 10.3% vs 50.3% ± 10.7%; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.

AB - Aim and patients: The aim of the present study is to evaluate the additional value of systolic wall thickening to myocardial perfusion in diagnosing myocardial stunning in patients with angiography proven coronary artery disease. We selected 91 ischemic patients (82 males; mean age 59.7 ± 10.3) with CAD documented by angiography. Ischemia was defined as a summed difference score ≥5. All patients underwent a 2-day gated perfusion SPECT protocol. The patients received a dose of 740 MBq of 99mTc-tetrofosmin after stress and at rest. Treadmill maximal exercise tests were performed on all patients.Results: The post-stress LVEF was significantly lower than rest LVEF (48.1% ± 10.3% vs 50.3% ± 10.7%; P = .0001). The wall thickening summed difference score was 4.44 ± 4.13 (P = .0001). At a multivariate regression analysis, only WT-SDS as independent variable was significantly correlated with myocardial ischemia (SDS). We also divided patients according to SDS in those with mild (SDS < 8) and severe (SDS ≥ 8) ischemia. WT-SDS, but not ∆LVEF, was significantly different between groups. Conclusions: WT-SDS, more than the depression in the global function (∆LVEF) of the left ventricle, correlates with the degree of ischemia and better identifies, when present, the stunning phenomenon.

KW - cardiac single-photon emission computed tomography

KW - Coronary artery disease

KW - ischemic heart disease

KW - myocardial stunning

UR - http://www.scopus.com/inward/record.url?scp=85033362406&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033362406&partnerID=8YFLogxK

U2 - 10.1007/s12350-017-1115-5

DO - 10.1007/s12350-017-1115-5

M3 - Article

VL - 26

SP - 833

EP - 840

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 3

ER -