Addressing Key Clinical Care and Clinical Research Needs in Severe Pediatric Traumatic Brain Injury: Perspectives From a Focused International Conference

Mirco Nacoti, Francesco Fazzi, Francesco Biroli, Rosalia Zangari, Tiziano Barbui, Patrick M. Kochanek, Sandra Strazzer, The Collaborative Pediatric TBI Working Group

Research output: Contribution to journalReview articlepeer-review

Abstract

Traumatic brain injury (TBI) is a leading cause of morbidity and mortality in children and adolescents. Survivors of severe TBI are more prone to functional deficits, resulting in poorer school performance, poor health-related quality of life (HRQoL), and increased risk of mental health problems. Critical gaps in knowledge of pathophysiological differences between children and adults concerning TBI outcomes, the paucity of pediatric trials and prognostic models and the uncertain extrapolation of adult data to pediatrics pose significant challenges and demand global efforts. Here, we explore the clinical and research unmet needs focusing on severe pediatric TBI to identify best practices in pathways of care and optimize both inpatient and outpatient management of children following TBI.

Original languageEnglish
Article number594425
Number of pages17
JournalFrontiers in Pediatrics
Volume8
DOIs
Publication statusPublished - Jan 18 2021

Keywords

  • intracranial pressure
  • outcomes
  • pediatric
  • prognosis
  • traumatic brain injury

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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