Addressing unmet needs in understanding asthma mechanisms

Michael R. Edwards, Sejal Saglani, Jurgen Schwarze, Chrysanthi Skevaki, Jaclyn A. Smith, Ben Ainsworth, Mark Almond, Evangelos Andreakos, Maria G. Belvisi, Kian Fan Chung, William O. Cookson, Paul Cullinan, Catherine Hawrylowicz, Marek Lommatzsch, David G. Jackson, Rene Lutter, Benjamin J. Marsland, Miriam F. Moffatt, Mike Thomas, J. Christian VirchowGeorgina Xanthou, Jessica Edwards, Samantha M. Walker, Sebastian L. Johnston, Ian M Adcock, Cezmi Akdis, Elisabeth Bel, Jean Bousquet, Anneke Ten Brinke, Guy G. Brusselle, Sven Erik Dáhlen, Ratko Djukanovic, Mina Gaga, Luis Garcia-Marcos, Pieter S. Hiemstra, Enrico Heffler, Stephen T. Holgate, Maciek Kupczyk, Clare M. Lloyd, Jane Lucas, Antoine Magnan, Thomas Martin, David Myles, Clive P. Page, Susanna Palkonen, Nikos Papadopoulos, Alberto Papi, Pippa Powell, John Riley, Antonio Spanevello, members of the EARIP WP2 working group12

Research output: Contribution to journalReview articlepeer-review


Asthma is a heterogeneous, complex disease with clinical phenotypes that incorporate persistent symptoms and acute exacerbations. It affects many millions of Europeans throughout their education and working lives and puts a heavy cost on European productivity. There is a wide spectrum of disease severity and control. Therapeutic advances have been slow despite greater understanding of basic mechanisms and the lack of satisfactory preventative and disease modifying management for asthma constitutes a significant unmet clinical need. Preventing, treating and ultimately curing asthma requires co-ordinated research and innovation across Europe. The European Asthma Research and Innovation Partnership (EARIP) is an FP7-funded programme which has taken a co-ordinated and integrated approach to analysing the future of asthma research and development. This report aims to identify the mechanistic areas in which investment is required to bring about significant improvements in asthma outcomes.

Original languageEnglish
Article number1602448
Pages (from-to)1-30
Number of pages30
JournalEuropean Respiratory Journal
Issue number5
Publication statusPublished - May 1 2017

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine


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