Ein spezielles Cloud-System für die Real-time‑/Vorab-Qualitätssicherung in der pädiatrischen Strahlentherapie

Translated title of the contribution: A dedicated cloud system for real-time upfront quality assurance in pediatric radiation therapy

Research output: Contribution to journalArticle

Abstract

Purpose: Pediatric radiotherapy (RT) is a highly specialized field, requiring great experience to delineate correctly tumor targets and organs at risk. To reduce treatment failures related to planning inaccuracies and to obtain robust clinical results despite the limited numbers of enrolled pediatric patients, the SIOP PNET5MB clinical trial on medulloblastoma requires a real-time, pre-radiation review of the RT treatment (craniospinal irradiation and boost plan) under the direct responsibility of the national coordinator center. Here we describe the centralized radiotherapy quality assurance (QA) program developed in Italy for this purpose. Methods: Using the software package VODCA (MSS, Hagendorn, Switzerland, www.vodca.ch), we developed a cloud platform able to handle computed tomography (CT) images and RT objects and to support the complete workflow required by the review process in the context of the SIOP PNET5 trial. Results: All Italian centers participating in the PNET5 trial adopted the proposed QA system. 24 patients were successfully enrolled and reviewed. For 15 patients (62.5%), one or more plan revisions were requested for the craniospinal irradiation plan and for 11 patients (45.8%) plan revisions were requested for the boost. RT was delivered after the plan was centrally approved for all enrolled patients. So far, in Italy, no patients have been excluded from PNET5 due to dosimetric incompliance to the protocol or for exceeding the RT starting time limit. Conclusion: The cloud platform successfully supported the trial workflow, producing official review documents. This efficient QA was crucial to guarantee optimized treatments and protocol compliance for all pediatric patients enrolled in the SIOP protocol.

Original languageGerman
JournalStrahlentherapie und Onkologie
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Computer Systems
Radiotherapy
Pediatrics
Craniospinal Irradiation
Workflow
Italy
Organs at Risk
Guideline Adherence
Medulloblastoma
Clinical Protocols
Treatment Failure
Switzerland
Software
Tomography
Clinical Trials
Radiation
Neoplasms

Keywords

  • Craniospinal irradiation
  • Medulloblastoma
  • Pediatric radiotherapy
  • Quality assurance
  • SIOP PNET 5 MB trial

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Oncology

Cite this

@article{d12fa60385b0415ca80a5e8442f5a9bb,
title = "Ein spezielles Cloud-System f{\"u}r die Real-time‑/Vorab-Qualit{\"a}tssicherung in der p{\"a}diatrischen Strahlentherapie",
abstract = "Purpose: Pediatric radiotherapy (RT) is a highly specialized field, requiring great experience to delineate correctly tumor targets and organs at risk. To reduce treatment failures related to planning inaccuracies and to obtain robust clinical results despite the limited numbers of enrolled pediatric patients, the SIOP PNET5MB clinical trial on medulloblastoma requires a real-time, pre-radiation review of the RT treatment (craniospinal irradiation and boost plan) under the direct responsibility of the national coordinator center. Here we describe the centralized radiotherapy quality assurance (QA) program developed in Italy for this purpose. Methods: Using the software package VODCA (MSS, Hagendorn, Switzerland, www.vodca.ch), we developed a cloud platform able to handle computed tomography (CT) images and RT objects and to support the complete workflow required by the review process in the context of the SIOP PNET5 trial. Results: All Italian centers participating in the PNET5 trial adopted the proposed QA system. 24 patients were successfully enrolled and reviewed. For 15 patients (62.5{\%}), one or more plan revisions were requested for the craniospinal irradiation plan and for 11 patients (45.8{\%}) plan revisions were requested for the boost. RT was delivered after the plan was centrally approved for all enrolled patients. So far, in Italy, no patients have been excluded from PNET5 due to dosimetric incompliance to the protocol or for exceeding the RT starting time limit. Conclusion: The cloud platform successfully supported the trial workflow, producing official review documents. This efficient QA was crucial to guarantee optimized treatments and protocol compliance for all pediatric patients enrolled in the SIOP protocol.",
keywords = "Craniospinal irradiation, Medulloblastoma, Pediatric radiotherapy, Quality assurance, SIOP PNET 5 MB trial",
author = "Silvia Meroni and Claudia Cavatorta and Salvina Barra and Francesca Cavagnetto and Giovanni Scarzello and Alessandro Scaggion and Emilia Pecori and Barbara Diletto and Ombretta Alessandro and Maura Massimino and Stefano Gianolini and Emanuele Pignoli and Lorenza Gandola",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00066-019-01469-y",
language = "Tedesco",
journal = "Strahlentherapie und Onkologie",
issn = "0179-7158",
publisher = "Urban und Vogel",

}

TY - JOUR

T1 - Ein spezielles Cloud-System für die Real-time‑/Vorab-Qualitätssicherung in der pädiatrischen Strahlentherapie

AU - Meroni, Silvia

AU - Cavatorta, Claudia

AU - Barra, Salvina

AU - Cavagnetto, Francesca

AU - Scarzello, Giovanni

AU - Scaggion, Alessandro

AU - Pecori, Emilia

AU - Diletto, Barbara

AU - Alessandro, Ombretta

AU - Massimino, Maura

AU - Gianolini, Stefano

AU - Pignoli, Emanuele

AU - Gandola, Lorenza

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Purpose: Pediatric radiotherapy (RT) is a highly specialized field, requiring great experience to delineate correctly tumor targets and organs at risk. To reduce treatment failures related to planning inaccuracies and to obtain robust clinical results despite the limited numbers of enrolled pediatric patients, the SIOP PNET5MB clinical trial on medulloblastoma requires a real-time, pre-radiation review of the RT treatment (craniospinal irradiation and boost plan) under the direct responsibility of the national coordinator center. Here we describe the centralized radiotherapy quality assurance (QA) program developed in Italy for this purpose. Methods: Using the software package VODCA (MSS, Hagendorn, Switzerland, www.vodca.ch), we developed a cloud platform able to handle computed tomography (CT) images and RT objects and to support the complete workflow required by the review process in the context of the SIOP PNET5 trial. Results: All Italian centers participating in the PNET5 trial adopted the proposed QA system. 24 patients were successfully enrolled and reviewed. For 15 patients (62.5%), one or more plan revisions were requested for the craniospinal irradiation plan and for 11 patients (45.8%) plan revisions were requested for the boost. RT was delivered after the plan was centrally approved for all enrolled patients. So far, in Italy, no patients have been excluded from PNET5 due to dosimetric incompliance to the protocol or for exceeding the RT starting time limit. Conclusion: The cloud platform successfully supported the trial workflow, producing official review documents. This efficient QA was crucial to guarantee optimized treatments and protocol compliance for all pediatric patients enrolled in the SIOP protocol.

AB - Purpose: Pediatric radiotherapy (RT) is a highly specialized field, requiring great experience to delineate correctly tumor targets and organs at risk. To reduce treatment failures related to planning inaccuracies and to obtain robust clinical results despite the limited numbers of enrolled pediatric patients, the SIOP PNET5MB clinical trial on medulloblastoma requires a real-time, pre-radiation review of the RT treatment (craniospinal irradiation and boost plan) under the direct responsibility of the national coordinator center. Here we describe the centralized radiotherapy quality assurance (QA) program developed in Italy for this purpose. Methods: Using the software package VODCA (MSS, Hagendorn, Switzerland, www.vodca.ch), we developed a cloud platform able to handle computed tomography (CT) images and RT objects and to support the complete workflow required by the review process in the context of the SIOP PNET5 trial. Results: All Italian centers participating in the PNET5 trial adopted the proposed QA system. 24 patients were successfully enrolled and reviewed. For 15 patients (62.5%), one or more plan revisions were requested for the craniospinal irradiation plan and for 11 patients (45.8%) plan revisions were requested for the boost. RT was delivered after the plan was centrally approved for all enrolled patients. So far, in Italy, no patients have been excluded from PNET5 due to dosimetric incompliance to the protocol or for exceeding the RT starting time limit. Conclusion: The cloud platform successfully supported the trial workflow, producing official review documents. This efficient QA was crucial to guarantee optimized treatments and protocol compliance for all pediatric patients enrolled in the SIOP protocol.

KW - Craniospinal irradiation

KW - Medulloblastoma

KW - Pediatric radiotherapy

KW - Quality assurance

KW - SIOP PNET 5 MB trial

UR - http://www.scopus.com/inward/record.url?scp=85065079776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85065079776&partnerID=8YFLogxK

U2 - 10.1007/s00066-019-01469-y

DO - 10.1007/s00066-019-01469-y

M3 - Articolo

AN - SCOPUS:85065079776

JO - Strahlentherapie und Onkologie

JF - Strahlentherapie und Onkologie

SN - 0179-7158

ER -