Adenoma-carcinoma sequence of colorectum prevalence of k-ras gene mutation in adenomas with increasing degree of dysplasia and aneuploidy

Renzo Ranaldi, Anna Maria Gioacchini, Aldo Manzin, Massimo Clementi, Stefania Paolucci, Italo Bearzi

Research output: Contribution to journalArticlepeer-review

Abstract

One hundred and fifty colorectal adenomas were investigated in order to detect the presence of K-ras gene mutation. The adenomas were classified according to the severity of the histological lesion (mild, moderate, or severe dysplasia and carcinomatous transformation) and to the degree of aneuploidy. K-ras mutation was found in 30.8% of cases, mostly consisting of a point mutation of codon 12. K-rai mutation was more frequently found in adenomas >1 cm and in the villous type. No correlation was otherwise demonstrable with the ploidy pattern of the lesion.

Original languageEnglish
Pages (from-to)198-202
Number of pages5
JournalDiagnostic Molecular Pathology
Volume4
Issue number3
Publication statusPublished - 1995

Keywords

  • Aneuploidy
  • Colorectal adenomas
  • Colorectal carcinoma
  • K-ras mutation

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology
  • Pathology and Forensic Medicine

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