Abstract
One hundred and fifty colorectal adenomas were investigated in order to detect the presence of K-ras gene mutation. The adenomas were classified according to the severity of the histological lesion (mild, moderate, or severe dysplasia and carcinomatous transformation) and to the degree of aneuploidy. K-ras mutation was found in 30.8% of cases, mostly consisting of a point mutation of codon 12. K-rai mutation was more frequently found in adenomas >1 cm and in the villous type. No correlation was otherwise demonstrable with the ploidy pattern of the lesion.
Original language | English |
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Pages (from-to) | 198-202 |
Number of pages | 5 |
Journal | Diagnostic Molecular Pathology |
Volume | 4 |
Issue number | 3 |
Publication status | Published - 1995 |
Keywords
- Aneuploidy
- Colorectal adenomas
- Colorectal carcinoma
- K-ras mutation
ASJC Scopus subject areas
- Cell Biology
- Molecular Biology
- Pathology and Forensic Medicine