Adenosine A {2A} receptor expression in peripheral blood mononuclear cells of patients with mild cognitive impairment

Beatrice Arosio, Chiara Viazzoli, Luigina Mastronardi, Claudio Bilotta, Carlo Vergani, Luigi Bergamaschini

Research output: Contribution to journalArticlepeer-review

Abstract

Adenosine suppresses immune responses through the adenosine A2A receptors (A2AR). We evaluated the expression of A2AR in blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer's disease (AD), and controls in order to verify if it may help distinguish different forms of cognitive decline. There was a significant linear increase in both mRNA levels and receptor density from multiple cognitive domain MCI (mcd-MCI) to amnestic MCI (a-MCI), spanning through AD and controls, without any significant difference between the latter two groups of subjects. These data, which need to be confirmed in a larger number of patients, suggest that expression of A2AR in PBMCs may be a valuable means of differentiating a-MCI and mcd-MCI.

Original languageEnglish
Pages (from-to)991-996
Number of pages6
JournalJournal of Alzheimer's Disease
Volume20
Issue number4
DOIs
Publication statusPublished - 2010

Keywords

  • Adenosine receptors
  • Alzheimer's disease
  • inflammation
  • mild cognitive impairment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Geriatrics and Gerontology
  • Clinical Psychology
  • Medicine(all)

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