Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium

Beatrice Arosio, Stefano Perlini, Carmen Calabresi, Rossana Tozzi, Giuseppina Palladini, Alberto U. Ferrari, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journalArticlepeer-review

Abstract

Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42±1, 38±2, 39±2 and 35±2, in 2-, 5-, 12- and 21-month-old rats; p1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p2A gene expression was lower in the aged LV (p1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.

Original languageEnglish
Pages (from-to)855-861
Number of pages7
JournalExperimental Gerontology
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

Keywords

  • Adenosine receptor
  • Ageing
  • Animal model
  • Gene expression
  • Heart

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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