Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium

Beatrice Arosio, Stefano Perlini, Carmen Calabresi, Rossana Tozzi, Giuseppina Palladini, Alberto U. Ferrari, Carlo Vergani, Giorgio Annoni

Research output: Contribution to journalArticle

Abstract

Adenosine (Ado), a naturally occurring autacoid, exerts cardioprotective effects against myocardial ischemia and reperfusion injury, through activation of its receptors type 1 (A1) and 2A (A2A). Since ageing involves a complex change in these effects, we evaluated A1 and A2A gene expression in left (LV) and right ventricle (RV) from 2-, 5-, 12-, and 21-month-old Sprague-Dawley rats. LV end-diastolic (EDD) and end-systolic (ESD) internal dimensions (mm) and LV fractional shortening (FS, %) were measured by M-mode echocardiography. Senescence was associated with a reduction in FS (42±1, 38±2, 39±2 and 35±2, in 2-, 5-, 12- and 21-month-old rats; p1 mRNA levels were highest in 12 and 21-month-old animals in both ventricles (LV: p2A gene expression was lower in the aged LV (p1 receptor mRNA may partially explain the stronger antiadrenergic effects of Ado in the senescent heart.

Original languageEnglish
Pages (from-to)855-861
Number of pages7
JournalExperimental Gerontology
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 1 2003

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Receptor Cross-Talk
Gene expression
Adenosine
Heart Ventricles
Rats
Myocardium
Aging of materials
Autacoids
Myocardial Reperfusion Injury
Gene Expression
Echocardiography
Messenger RNA
Adrenergic Antagonists
Reperfusion Injury
Myocardial Ischemia
Sprague Dawley Rats
Animals
Chemical activation

Keywords

  • Adenosine receptor
  • Ageing
  • Animal model
  • Gene expression
  • Heart

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium. / Arosio, Beatrice; Perlini, Stefano; Calabresi, Carmen; Tozzi, Rossana; Palladini, Giuseppina; Ferrari, Alberto U.; Vergani, Carlo; Annoni, Giorgio.

In: Experimental Gerontology, Vol. 38, No. 8, 01.08.2003, p. 855-861.

Research output: Contribution to journalArticle

Arosio, B, Perlini, S, Calabresi, C, Tozzi, R, Palladini, G, Ferrari, AU, Vergani, C & Annoni, G 2003, 'Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium', Experimental Gerontology, vol. 38, no. 8, pp. 855-861. https://doi.org/10.1016/S0531-5565(03)00095-0
Arosio, Beatrice ; Perlini, Stefano ; Calabresi, Carmen ; Tozzi, Rossana ; Palladini, Giuseppina ; Ferrari, Alberto U. ; Vergani, Carlo ; Annoni, Giorgio. / Adenosine A1 and A2A receptor cross-talk during ageing in the rat myocardium. In: Experimental Gerontology. 2003 ; Vol. 38, No. 8. pp. 855-861.
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