Abstract
Adenosine suppresses immune responses through the A2A receptor (A2AR). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A2AR in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A2AR in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A2AR mRNA levels and A 2AR density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67 in a-MCI, 46 in AD, 35 in mcd-MCI, and 20 in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A2AR in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.
| Original language | English |
|---|---|
| Article number | 484021 |
| Journal | International Journal of Alzheimer's Disease |
| DOIs | |
| Publication status | Published - 2011 |
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ASJC Scopus subject areas
- Clinical Neurology
- Behavioral Neuroscience
- Cognitive Neuroscience
- Ageing
- Cellular and Molecular Neuroscience
- Neurology
Cite this
Adenosine A2A receptor and IL-10 in peripheral blood mononuclear cells of patients with mild cognitive impairment. / Arosio, Beatrice; Mastronardi, Luigina; Gussago, Cristina; Nicolini, Paola; Casè, Alessandra; Ziglioli, Eleonora; Bergamaschini, Luigi.
In: International Journal of Alzheimer's Disease, 2011.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Adenosine A2A receptor and IL-10 in peripheral blood mononuclear cells of patients with mild cognitive impairment
AU - Arosio, Beatrice
AU - Mastronardi, Luigina
AU - Gussago, Cristina
AU - Nicolini, Paola
AU - Casè, Alessandra
AU - Ziglioli, Eleonora
AU - Bergamaschini, Luigi
PY - 2011
Y1 - 2011
N2 - Adenosine suppresses immune responses through the A2A receptor (A2AR). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A2AR in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A2AR in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A2AR mRNA levels and A 2AR density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67 in a-MCI, 46 in AD, 35 in mcd-MCI, and 20 in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A2AR in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.
AB - Adenosine suppresses immune responses through the A2A receptor (A2AR). This study investigated the interleukin 10 (IL-10) genetic profile and the expression of A2AR in peripheral blood mononuclear cells (PBMCs) of patients with mild cognitive impairment (MCI), Alzheimer disease (AD), and age-matched controls to verify, if they may help distinguish different forms of cognitive decline. We analyzed the IL-10 genotype and the expression of A2AR in 41 subjects with AD, 10 with amnestic MCI (a-MCI), 49 with multiple cognitive domain MCI (mcd-MCI), and 46 controls. There was a significant linear increase in A2AR mRNA levels and A 2AR density from mcd-MCI to a-MCI, with intermediate levels being found in AD. The IL-10 AA genotype frequency was 67 in a-MCI, 46 in AD, 35 in mcd-MCI, and 20 in controls. These data suggest that the assessment of the IL-10 genotype and the expression of A2AR in PBMCs may be a valuable means of differentiating between a-MCI and mcd-MCI.
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UR - http://www.scopus.com/inward/citedby.url?scp=79959194321&partnerID=8YFLogxK
U2 - 10.4061/2011/484021
DO - 10.4061/2011/484021
M3 - Article
C2 - 21629668
AN - SCOPUS:79959194321
JO - International Journal of Alzheimer's Disease
JF - International Journal of Alzheimer's Disease
SN - 2090-8024
M1 - 484021
ER -