Abstract
This study compared the results of adenosine 99mTc-tetrofosmin cardiac tomography with those of adenosine echocardiography in identifying patients with coronary artery disease (CAD) and in localizing individual stenosed coronary vessels. Methods: Twenty-six consecutive patients with suspected or known CAD had simultaneous adenosine (140 μg/Kg/min intravenously) 99mTc-tetrofosmin tomography and two-dimensional echocardiography. All patients had coronary angiography within 4 wk from imaging studies. Regional 99mTc-tetrofosmin activity was quantitatively measured in 78 coronary vascular territories and echocardiographic left ventricular function was assessed in corresponding regions. Results: At coronary angiography one patient had normal coronary vessels, 12 patients one-vessel and 13 had multivessel disease (≤50% luminal stenosis). Among the 25 patients with CAD, 22 showed perfusion defects at adenosine 99mTc- tetrofosmin tomography (sensitivity 88%) and 17 had abnormal echocardiographic study (sensitivity 68%, p <0.05 versus 99mTc- tetrofosmin). Agreement for the identification of patients with CAD between adenosine 99mTc-tetrofosmin tomography and echocardiography was observed in 21 (81%) of the total 26 patients, with a kappa value of 0.45. Overall sensitivity, specificity and diagnostic accuracy for detection of individual stenosed vessels were 79%, 88% and 83% for 99mTC tetrofosmin and 57%, 68% and 61% (all p <0.05 versus 99mTc-tetrofosmin) for echocardiography. Concordance between adenosine 99mTc-tetrofosmin tomography and echocardiography in the detection of individual stenosed coronary vessels was observed in 57 (73%) of the 78 vascular territories, with a kappa value of 0.36. Conclusion: Adenosine-induced coronary vasodilation associated with quantitative 99mTc-tetrofosmin tomography is more accurate than adenosine echocardiography in identifying patients with CAD and in detecting individual stenosed coronary vessels.
| Original language | English |
|---|---|
| Pages (from-to) | 1089-1094 |
| Number of pages | 6 |
| Journal | Journal of Nuclear Medicine |
| Volume | 38 |
| Issue number | 7 |
| Publication status | Published - 1997 |
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Keywords
- Left ventricular function
- Myocardial perfusion
- Pharmacologic stress test
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Adenosine coronary vasodilation in coronary artery disease : Technetium- 99m tetrofosmin myocardial tomography versus echocardiography. / Cuocolo, A.; Sullo, P.; Pace, L.; Nappi, A.; Gisonni, P.; Nicolai, E.; Trimarco, B.; Salvatore, M.
In: Journal of Nuclear Medicine, Vol. 38, No. 7, 1997, p. 1089-1094.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Adenosine coronary vasodilation in coronary artery disease
T2 - Technetium- 99m tetrofosmin myocardial tomography versus echocardiography
AU - Cuocolo, A.
AU - Sullo, P.
AU - Pace, L.
AU - Nappi, A.
AU - Gisonni, P.
AU - Nicolai, E.
AU - Trimarco, B.
AU - Salvatore, M.
PY - 1997
Y1 - 1997
N2 - This study compared the results of adenosine 99mTc-tetrofosmin cardiac tomography with those of adenosine echocardiography in identifying patients with coronary artery disease (CAD) and in localizing individual stenosed coronary vessels. Methods: Twenty-six consecutive patients with suspected or known CAD had simultaneous adenosine (140 μg/Kg/min intravenously) 99mTc-tetrofosmin tomography and two-dimensional echocardiography. All patients had coronary angiography within 4 wk from imaging studies. Regional 99mTc-tetrofosmin activity was quantitatively measured in 78 coronary vascular territories and echocardiographic left ventricular function was assessed in corresponding regions. Results: At coronary angiography one patient had normal coronary vessels, 12 patients one-vessel and 13 had multivessel disease (≤50% luminal stenosis). Among the 25 patients with CAD, 22 showed perfusion defects at adenosine 99mTc- tetrofosmin tomography (sensitivity 88%) and 17 had abnormal echocardiographic study (sensitivity 68%, p <0.05 versus 99mTc- tetrofosmin). Agreement for the identification of patients with CAD between adenosine 99mTc-tetrofosmin tomography and echocardiography was observed in 21 (81%) of the total 26 patients, with a kappa value of 0.45. Overall sensitivity, specificity and diagnostic accuracy for detection of individual stenosed vessels were 79%, 88% and 83% for 99mTC tetrofosmin and 57%, 68% and 61% (all p <0.05 versus 99mTc-tetrofosmin) for echocardiography. Concordance between adenosine 99mTc-tetrofosmin tomography and echocardiography in the detection of individual stenosed coronary vessels was observed in 57 (73%) of the 78 vascular territories, with a kappa value of 0.36. Conclusion: Adenosine-induced coronary vasodilation associated with quantitative 99mTc-tetrofosmin tomography is more accurate than adenosine echocardiography in identifying patients with CAD and in detecting individual stenosed coronary vessels.
AB - This study compared the results of adenosine 99mTc-tetrofosmin cardiac tomography with those of adenosine echocardiography in identifying patients with coronary artery disease (CAD) and in localizing individual stenosed coronary vessels. Methods: Twenty-six consecutive patients with suspected or known CAD had simultaneous adenosine (140 μg/Kg/min intravenously) 99mTc-tetrofosmin tomography and two-dimensional echocardiography. All patients had coronary angiography within 4 wk from imaging studies. Regional 99mTc-tetrofosmin activity was quantitatively measured in 78 coronary vascular territories and echocardiographic left ventricular function was assessed in corresponding regions. Results: At coronary angiography one patient had normal coronary vessels, 12 patients one-vessel and 13 had multivessel disease (≤50% luminal stenosis). Among the 25 patients with CAD, 22 showed perfusion defects at adenosine 99mTc- tetrofosmin tomography (sensitivity 88%) and 17 had abnormal echocardiographic study (sensitivity 68%, p <0.05 versus 99mTc- tetrofosmin). Agreement for the identification of patients with CAD between adenosine 99mTc-tetrofosmin tomography and echocardiography was observed in 21 (81%) of the total 26 patients, with a kappa value of 0.45. Overall sensitivity, specificity and diagnostic accuracy for detection of individual stenosed vessels were 79%, 88% and 83% for 99mTC tetrofosmin and 57%, 68% and 61% (all p <0.05 versus 99mTc-tetrofosmin) for echocardiography. Concordance between adenosine 99mTc-tetrofosmin tomography and echocardiography in the detection of individual stenosed coronary vessels was observed in 57 (73%) of the 78 vascular territories, with a kappa value of 0.36. Conclusion: Adenosine-induced coronary vasodilation associated with quantitative 99mTc-tetrofosmin tomography is more accurate than adenosine echocardiography in identifying patients with CAD and in detecting individual stenosed coronary vessels.
KW - Left ventricular function
KW - Myocardial perfusion
KW - Pharmacologic stress test
UR - http://www.scopus.com/inward/record.url?scp=0030855502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030855502&partnerID=8YFLogxK
M3 - Article
C2 - 9225796
AN - SCOPUS:0030855502
VL - 38
SP - 1089
EP - 1094
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 7
ER -