Adenosine deaminase activity in peripheral lymphocytes of patients with gynaecologic malignancies.

G. Specchia, V. Pavone, F. Maggio, L. Lojudice, A. Iacobazzi, L. De Tullio, G. Cagnazzo, V. Liso

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Peripheral lymphocyte adenosine deaminase (ADA) activity was assessed in a group of 31 patients with gynaecologic malignancies (19 with carcinoma of the portio, 7 with endometrial adenocarcinoma, 3 with ovarian cancer, 1 with adenocarcinoma of the cervix, 1 with liposarcoma myxoide). 30 female subjects, aged 30 to 70 years, were studied as the control group. Lymphocyte ADA activity in the 31 patients ranged from 0 to 7 U/10(7) cells with a mean of 2.3 U/10(7) cells (normal values: range 2-5 U/10(7) cells; mean 2.8 U/10(7) cells). In cases where the enzyme was absent or far below the controls, a faster evolution of the disease was observed. We would point out that lymphocyte ADA activity in the patients under investigations shows a broad range of variability. Our preliminary observations would suggest that lymphocyte ADA assessment in a larger series of cancer patients may add further prognostic informations.

Original languageEnglish
Pages (from-to)404-407
Number of pages4
JournalBollettino dell'Istituto Sieroterapico Milanese
Issue number5
Publication statusPublished - 1985

ASJC Scopus subject areas

  • Immunology


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