Adenosine technetium-99m-methoxy isobutyl isonitrile myocardial tomography in patients with coronary artery disease: Comparison with exercise

A. Cuocolo, A. Soricelli, L. Pace, E. Nicolai, L. Castelli, A. Nappi, M. Imbriaco, C. Morisco, P. J. Ell, M. Salvatore

Research output: Contribution to journalArticle

Abstract

We compared the results of adenosine and bicycle exercise 99mTc- methoxy isobutyl isonitrile (MIBI) myocardial SPECT in 22 patients (18 males and 4 females, mean age 51 ± 11 yr) with angiographically documented coronary artery disease (CAD). Methods: All patients were submitted on separate days to three intravenous injections of 99mTc-MIBI (20 mCi); one at rest, one during exercise and one during adenosine (140 μg/kg per min for 6 min with injection of 99mTc-MIBI at 4 min). A total of 484 myocardial segments were quantitatively analyzed. Results: Adenosine induced a significant increase of heart rate (94 ± 16 bpm at peak versus 70 ± 13 bpm at rest, p <0.01). Systolic and diastolic blood pressure were not significantly different after adenosine infusion compared to rest. In all segments, a significant relationship between exercise and adenosine 99mTc- MIBI uptake was observed (r = 0.90, p <0.0001). Concordance between the two studies for identification of perfusion status was observed in 438 (90%) of the 484 segments (kappa value of 0.81). Agreement on localization of the perfusion defect to a specific vascular territory was 92%. Conclusion: Despite different hemodynamic effects, adenosine and exercise 99mTc-MIBI SPECT imaging provide similar information in the diagnosis and localization of CAD.

Original languageEnglish
Pages (from-to)1110-1115
Number of pages6
JournalJournal of Nuclear Medicine
Volume35
Issue number7
Publication statusPublished - 1994

Keywords

  • adenosine infusion
  • myocardial perfusion
  • technetium-99m-methoxy isobutyl isonitrile

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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