TY - JOUR
T1 - Adenosine technetium-99m-methoxy isobutyl isonitrile myocardial tomography in patients with coronary artery disease
T2 - Comparison with exercise
AU - Cuocolo, A.
AU - Soricelli, A.
AU - Pace, L.
AU - Nicolai, E.
AU - Castelli, L.
AU - Nappi, A.
AU - Imbriaco, M.
AU - Morisco, C.
AU - Ell, P. J.
AU - Salvatore, M.
PY - 1994
Y1 - 1994
N2 - We compared the results of adenosine and bicycle exercise 99mTc- methoxy isobutyl isonitrile (MIBI) myocardial SPECT in 22 patients (18 males and 4 females, mean age 51 ± 11 yr) with angiographically documented coronary artery disease (CAD). Methods: All patients were submitted on separate days to three intravenous injections of 99mTc-MIBI (20 mCi); one at rest, one during exercise and one during adenosine (140 μg/kg per min for 6 min with injection of 99mTc-MIBI at 4 min). A total of 484 myocardial segments were quantitatively analyzed. Results: Adenosine induced a significant increase of heart rate (94 ± 16 bpm at peak versus 70 ± 13 bpm at rest, p <0.01). Systolic and diastolic blood pressure were not significantly different after adenosine infusion compared to rest. In all segments, a significant relationship between exercise and adenosine 99mTc- MIBI uptake was observed (r = 0.90, p <0.0001). Concordance between the two studies for identification of perfusion status was observed in 438 (90%) of the 484 segments (kappa value of 0.81). Agreement on localization of the perfusion defect to a specific vascular territory was 92%. Conclusion: Despite different hemodynamic effects, adenosine and exercise 99mTc-MIBI SPECT imaging provide similar information in the diagnosis and localization of CAD.
AB - We compared the results of adenosine and bicycle exercise 99mTc- methoxy isobutyl isonitrile (MIBI) myocardial SPECT in 22 patients (18 males and 4 females, mean age 51 ± 11 yr) with angiographically documented coronary artery disease (CAD). Methods: All patients were submitted on separate days to three intravenous injections of 99mTc-MIBI (20 mCi); one at rest, one during exercise and one during adenosine (140 μg/kg per min for 6 min with injection of 99mTc-MIBI at 4 min). A total of 484 myocardial segments were quantitatively analyzed. Results: Adenosine induced a significant increase of heart rate (94 ± 16 bpm at peak versus 70 ± 13 bpm at rest, p <0.01). Systolic and diastolic blood pressure were not significantly different after adenosine infusion compared to rest. In all segments, a significant relationship between exercise and adenosine 99mTc- MIBI uptake was observed (r = 0.90, p <0.0001). Concordance between the two studies for identification of perfusion status was observed in 438 (90%) of the 484 segments (kappa value of 0.81). Agreement on localization of the perfusion defect to a specific vascular territory was 92%. Conclusion: Despite different hemodynamic effects, adenosine and exercise 99mTc-MIBI SPECT imaging provide similar information in the diagnosis and localization of CAD.
KW - adenosine infusion
KW - myocardial perfusion
KW - technetium-99m-methoxy isobutyl isonitrile
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M3 - Article
C2 - 8014666
AN - SCOPUS:0028318849
VL - 35
SP - 1110
EP - 1115
JO - Journal of Nuclear Medicine
JF - Journal of Nuclear Medicine
SN - 0161-5505
IS - 7
ER -