Adenosine Type A2A Receptor in Peripheral Cell from Patients with Alzheimer's Disease, Vascular Dementia, and Idiopathic Normal Pressure Hydrocephalus: A New/Old Potential Target

Beatrice Arosio, Martina Casati, Cristina Gussago, Evelyn Ferri, Carlo Abbate, Valeria Scortichini, Elena Colombo, Paolo Dionigi Rossi, Daniela Mari

Research output: Contribution to journalReview articlepeer-review

Abstract

As the European population gets older, the incidence of neurological disorders increases with significant impact on social costs. Despite differences in disease etiology, several brain disorders in the elderly (e.g., Alzheimer's disease, vascular dementia, normal pressure hydrocephalus) share dementia as a common clinical feature. The current treatment for the majority of these diseases is merely symptomatic and does not modify the course of the illness. Symptoms of normal pressure hydrocephalus are the only ones that can be modified if they are recognized in time and treated appropriately. Therefore, an important clinical strategy may be disclosed by pathogenic pathways that can be modified and to find drugs that can slow down or even arrest disease progression. Possibly a way to answer this question could be by re-examining all the molecules which have so far succeeded in improving many aspects of cognitive deterioration in some neurodegenerative conditions, that were not considered because of controversial opinions. The main purpose of this summary is to further substantiate the hypothesis that the pathway of adenosine type A2A receptor could be used as a potential target to develop new/old therapeutic strategies.

Original languageEnglish
Pages (from-to)417-425
Number of pages9
JournalJournal of Alzheimer's Disease
Volume54
Issue number2
DOIs
Publication statusPublished - Sep 6 2016

Keywords

  • Adenosine
  • adenosine receptors
  • elderly
  • neurodegeneration

ASJC Scopus subject areas

  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

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